Synthesis, characterization and DNA binding and cleavage properties of ruthenium(II) complexes with various polypyridyls

被引：9
|
作者：
Patel, Mohan N. [1 ]
Parmar, Pradhuman A. [1 ]
Gandhi, Deepen S. [1 ]
机构：
[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2011年 / 26卷 / 05期
关键词：
Ruthenium(II) complexes; Polypyridyl; intercalation; gel electrophoresis; PHOTOCLEAVAGE; CHEMISTRY;
D O I：
10.3109/14756366.2011.570007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polypyridyl chlororuthenium(II) complexes have been synthesized and characterized. The binding mode of the complexes to DNA has been evaluated from the combined results of electronic absorption spectroscopy and viscosity measurement study. The results suggest that complexes 1, 2 and 3 bind to DNA via classical intercalation, electrostatic interaction and partial intercalation mode, respectively. Complex 2 shows less affinity for DNA. Cleavage of pUC19 DNA by complexes has been checked using gel electrophoresis. The data disclose that complex 1 has the highest cleaving ability.
引用
收藏
页码：734 / 741
页数：8
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