Low-wavenumber Raman spectral database of pharmaceutical excipients

The interest in applications of low-wavenumber Raman (LWR) spectroscopy for pharmaceutical analysis has increased rapidly over the last decade. In this study, a collection of LWR spectra are presented for 75 commonly used pharmaceutical excipients, which serve an important role in the manufacture and delivery of pharmaceutics. The excipients were divided into 10 main groups based on chemical composition: amino acids, mono-and disaccharides, polysaccharides, monomeric polyols, esters, inorganic substances, organosulfates and carboxylic acids/salts, protein, polymers and others. The spectral data is intended to serve as a reference for a number of general purposes such as qualitative and quantitative analysis, counterfeit detection and pharmaceutical process control.