Successful management of an arteriovenous malformation with trametinib in a patient with capillary-malformation arteriovenous malformation syndrome and cardiac compromise

被引：34

作者：

Nicholson, Cynthia L. ^{[1
]}

Flanagan, Siobhan ^{[2
]}

Murati, Michael ^{[2
]}

Boull, Christina ^{[1
]}

McGough, Erin ^{[3
]}

Ameduri, Rebecca ^{[4
]}

Weigel, Brenda ^{[3
]}

Maguiness, Sheilagh ^{[1
]}

机构：

[1] Univ Minnesota, Dept Dermatol, 2450 Riverside Ave, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Pediat Radiol, Minneapolis, MN USA

[3] Univ Minnesota, Dept Pediat Hematol Oncol, Minneapolis, MN USA

[4] Univ Minnesota, Dept Pediat Cardiol, Minneapolis, MN USA

来源：

PEDIATRIC DERMATOLOGY | 2022年 / 39卷 / 02期

关键词：

MEK inhibitor; skin signs of systemic disease; therapy-systemic; trametinib; vascular malformation;

D O I：

10.1111/pde.14912

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is an autosomal dominant condition characterized by multifocal, noncontiguous pink patches on the skin that often have a surrounding pale halo. In some cases, an association with a fast flow, arteriovenous malformation (AVM) can be identified. Here, we describe a case report of a 16-year-old woman with CM-AVM syndrome and significant cardiac compromise successfully treated with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.

引用

页码：316 / 319

页数：4

共 50 条

[1] Capillary-venule malformation is a microfistulous variant of arteriovenous malformation
Vuillemin, Nicolas
Bernhard, Sarah
Haine, Axel
Schindewolf, Marc
Haberli, Dario
Hugel, Ulrike
Obrist, Dominik
Baumgartner, Iris
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS, 2021, 9 (01) : 220 - 225
[2] Atypical capillary malformations with subsequent diplegia: A difficult case of capillary malformation-arteriovenous malformation syndrome
Plumptre, Isabella
Robertson, Fergus
Rennie, Adam
James, Greg
Syed, Samira B.
PEDIATRIC DERMATOLOGY, 2020, 37 (01) : 162 - 164
[3] Cardiac arteriovenous malformation causing sudden death
Aguilera, B
Suárez-Mier, MP
Argente, T
CARDIOVASCULAR PATHOLOGY, 2004, 13 (05) : 296 - 298
[4] Use of Carotid Compression in a Patient with Arteriovenous Malformation
Coca, Javier
Romero, Ricardo
Sanchez-Orgaz, Margarita
Arbizu, Alvaro
Frutos-Martinez, Ramon
Fernandez-Prieto, Arancha
Marin-Aguilera, Begona
ORBIT-AN INTERNATIONAL JOURNAL ON ORBITAL DISORDERS AND FACIAL RECONSTRUCTIVE SURGERY, 2013, 32 (01): : 63 - 66
[5] Retroperitoneal capillary arteriovenous malformation mimicking a malignant neoplasm
Yanagida, Kazuki
Kaneko, Tomoyuki
Saito, Koji
Yamamoto, Masayoshi
Yamamoto, Asako
Yamada, Yukio
Nakagawa, Tohru
IJU CASE REPORTS, 2023, 6 (06) : 398 - 401
[6] Endovascular Treatment of Arteriovenous Malformation
Robert Juszkat
Bartosz Żabicki
Paweł Chęciński
Marcin Gabriel
Nawal Matar
Aesthetic Plastic Surgery, 2009, 33 : 639 - 642
[7] Endovascular Treatment of Arteriovenous Malformation
Juszkat, Robert
Zabicki, Bartosz
Checinski, Pawel
Gabriel, Marcin
Matar, Nawal
AESTHETIC PLASTIC SURGERY, 2009, 33 (04) : 639 - 642
[8] Giant scalp arteriovenous malformation
Worm, Paulo Valdeci
Ruschel, Leonardo Gilmone
Roxo, Marcelo Rosa
Camelo, Rafael
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2016, 62 (09): : 828 - 830
[9] Single dominant lesion in capillary malformation-arteriovenous malformation (CM-AVM) RASA1 syndrome
Sanchez-Espino, Luis Fernando
Ivars, Marta
Torres, Carolina Prat
Lavarino, Cinzia E.
Olaciregui, Nagore Gene
Zurriaga, Carlota Rovira
Passini, Veronica P. Celis
Serrano, Miguel Bejarano
Baselga, Eulalia
PEDIATRIC DERMATOLOGY, 2024, 41 (05) : 861 - 865
[10] Capillary Malformation-Arteriovenous Malformation Combined Alagille Syndrome in a Patient With Double Gene Variations of RASA1 and NOTCH2
Zheng, Yu
Peng, Yuming
Zhang, Shuju
Li, Liping
Peng, Yu
Yin, Qiang
FRONTIERS IN GENETICS, 2019, 10

← 1 2 3 4 5 →