Comparative antiviral (HIV) photoactivity of metalized meso-tetraphenylsulfonated porphyrins

被引：8

作者：

Vargas, Franklin ^{[1
]}

Rivas, Carlos ^{[1
]}

Zoltan, Tamara ^{[1
]}

Padron, Liliana

Izzo, Carla ^{[1
]}

Lopez, Veronica ^{[1
]}

Gomez, Lubmir ^{[1
]}

Pujol, Flor ^{[2
]}

Rangel, Hector ^{[2
]}

Garzaro, Domingo ^{[2
]}

Fabbro, Rona ^{[2
]}

机构：

[1] Ctr Quim, Inst Venezolano Invest Cient, Caracas 1020A, Apartado, Venezuela

[2] Inst Venezolano Invest Cient, Ctr Microbiol & Biol Celular, Mol Virol Lab, Caracas, Venezuela

来源：

MEDICINAL CHEMISTRY | 2008年 / 4卷 / 02期

关键词：

meso-tetraphenylsulfonated porphyrins; HIV; metallo porphyrins; photoinactivation; phototherapy; phototoxicity; photosensitizer; antiviral; singlet oxygen;

D O I：

10.2174/157340608783789167

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have carried out the study of the photochemical properties of a series of synthetic meso-tetraphenylsulfonated porphyrins (TPPMS4) bonded to several metal ions such as: Cu(II), Zn(II), Pd(II), Mn(II), Fe(III), Ni(II) and Co(II) for the optimization of their clinical applications as antiviral agents against the human immunodeficiency virus (HIV-1) as well as the study of the in vitro antiviral photoinactivation mechanisms with future application in blood sterilization. A selective inhibition has been determined in the viral growth (HIV-1) when this is irradiated in the presence of the complex TPPFeS4 and TPPMnS4 (photosensitizer- mediated Type I reaction) as well as in the O-1(2)-mediated (Type II reaction) in the presence of TPPPdS4 and TPPZnS4, remaining cellular viability unaltered in each case.

引用

页码：138 / 145

页数：8

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