How does calcium trigger neurotransmitter release?

被引：303

作者：

Augustine, GJ ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(00)00214-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.

引用

页码：320 / 326

页数：7

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