The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function

被引：6

作者：

Subramanyam, Sudheendra Hebbar ^{[1
]}

Tenbrock, Klaus ^{[1
,2
,3
]}

机构：

[1] Rhein Westfal TH Aachen, Dept Pediat Pediat Pneumol Allergol & Immunol, Aachen, Germany

[2] Interdisciplinary Ctr Clin Res IZKF, Aachen, Germany

[3] Interdisciplinary Ctr Clin Res IZKF, Munster, Germany

来源：

BIOLOGICAL CHEMISTRY | 2021年 / 402卷 / 12期

关键词：

cAMP; CREM alpha; ICER; interleukin; 2; metabolism; Th17; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IL-2; PRODUCTION; EXPRESSION; ACTIVATION; PROMOTER; BINDING; GENE; ICER; AUTOIMMUNITY; SUPPRESSION;

D O I：

10.1515/hsz-2021-0249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cAMP responsive element modulator (CREM) is a transcriptional regulator of different effector cytokines in CD4(+) T cells including IL-2, IL-17, IL-21 but also IL-4 and IL-13 and thus an important determinant of central T helper cell functions. Our review gives an overview over the regulation of CREM in T cells and the pleiotropic effects of CREM on CD4(+) T cells in health and autoimmune diseases with a particular focus on systemic lupus erythematosus.

引用

页码：1591 / 1596

页数：6

共 34 条

[1] Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB
Asahara, H
Santoso, B
Guzman, E
Du, KY
Cole, PA
Davidson, I
Montminy, M
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (23) : 7892 - 7900
[2] Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB
Barton, K
Muthusamy, N
Chanyangam, M
Fischer, C
Clendenin, C
Leiden, JM
[J]. NATURE, 1996, 379 (6560) : 81 - 85
[3] Frontline: ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells
Bodor, Josef
Fehervari, Zoltan
Diamond, Betty
Sakaguchi, Shimon
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (04) : 884 - 895
[4] Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells
Cardone, John
Le Friec, Gaelle
Vantourout, Pierre
Roberts, Andrew
Fuchs, Anja
Jackson, Ian
Suddason, Tesha
Lord, Graham
Atkinson, John P.
Cope, Andrew
Hayday, Adrian
Kemper, Claudia
[J]. NATURE IMMUNOLOGY, 2010, 11 (09) : 862 - U123
[5] CBP-independent activation of CREM and CREB by the LIM-only protein ACT
Fimia, GM
De Cesare, D
Sassone-Corsi, P
[J]. NATURE, 1999, 398 (6723) : 165 - 169
[6] CREM GENE - USE OF ALTERNATIVE DNA-BINDING DOMAINS GENERATES MULTIPLE ANTAGONISTS OF CAMP-INDUCED TRANSCRIPTION
FOULKES, NS
BORRELLI, E
SASSONECORSI, P
[J]. CELL, 1991, 64 (04) : 739 - 749
[7] cAMP Responsive Element Modulator (CREM) α Mediates Chromatin Remodeling of CD8 during the Generation of CD3+CD4-CD8- T Cells
Hedrich, Christian M.
Crispin, Jose C.
Rauen, Thomas
Ioannidis, Christina
Koga, Tomohiro
Rodriguez, Noe Rodriguez
Apostolidis, Sokratis A.
Kyttaris, Vasileios C.
Tsokos, George C.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (04) : 2361 - 2370
[8] cAMP Response Element Modulator a Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus
Hofmann, Sigrun R.
Mabert, Katrin
Kapplusch, Franz
Russ, Susanne
Northey, Sarah
Beresford, Michael W.
Tsokos, George C.
Hedrich, Christian M.
[J]. JOURNAL OF IMMUNOLOGY, 2019, 203 (11) : 2807 - 2816
[9] Suppression of Autoimmunity and Organ Pathology in Lupus-Prone Mice Upon Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Type IV
Ichinose, Kunihiro
Juang, Yuang-Taung
Crispin, Jose C.
Kis-Toth, Katalin
Tsokos, George C.
[J]. ARTHRITIS AND RHEUMATISM, 2011, 63 (02): : 523 - 529
[10] Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
Juang, YT
Wang, Y
Solomou, EE
Li, YS
Mawrin, C
Tenbrock, K
Kyttaris, VC
Tsokos, C
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (04) : 996 - 1005

← 1 2 3 4 →