Enantioselective Allylic Etherification: Selective Coupling of Two Unactivated Alcohols

被引：147

作者：

Roggen, Markus ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 24期

关键词：

alcohols; allylic substitution; asymmetric synthesis; homogeneous catalysis; iridium; ASYMMETRIC-SYNTHESIS; KINETIC RESOLUTION; LIGANDS; SUBSTITUTION; ALKYLATION; ALLYLATION; PHENOLS; COMPLEX; AMINES; CARBONATES;

D O I：

10.1002/anie.201007716

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An Ir(P,alkene) complex catalyzes the enantioselective allylic etherification of unactivated secondary allylic alcohols. Useful levels of enantioselectivity and yield were achieved with this operationally easy and robust protocol. Initial kinetic studies indicate a significant rate difference for the substrate enantiomers, allowing for a resolution process. cod=1,5-cyclooctadiene Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5568 / 5571

页数：4

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