Update on Statin Treatment in Patients with Neuropsychiatric Disorders

被引：23

作者：

Avan, Razieh ^{[1
]}

Sahebnasagh, Adeleh ^{[2
]}

Hashemi, Javad ^{[3
]}

Monajati, Mahila ^{[4
]}

Faramarzi, Fatemeh ^{[5
]}

Henney, Neil C. ^{[6
]}

Montecucco, Fabrizio ^{[7
,8
]}

Jamialahmadi, Tannaz ^{[9
]}

Sahebkar, Amirhossein ^{[10
,11
,12
]}

机构：

[1] Birjand Univ Med Sci, Sch Pharm, Dept Clin Pharm, Med Toxicol & Drug Abuse Res Ctr MTDRC, Birjand 9717853577, Iran

[2] North Khorasan Univ Med Sci, Dept Internal Med, Clin Res Ctr, Bojnurd 9453155166, Iran

[3] North Khorasan Univ Med Sci, Sch Med, Dept Pathobiol & Lab Sci, Bojnurd 9453155166, Iran

[4] Golestan Univ Med Sci, Dept Internal Med, Gorgan 4934174515, Golestan, Iran

[5] Iran Univ Med Sci, Clin Pharm Res Ctr, Tehran 1445613131, Iran

[6] Liverpool John Moores Univ, Pharm & Biomol Sci, Liverpool L3 5UX, Merseyside, England

[7] IRCCS Osped Policlin San Martino Genoa, Italian Cardiovasc Network, 10 Largo Benzi, I-16132 Genoa, Italy

[8] Univ Genoa, Dept Internal Med, Clin Internal Med 1, 6 Viale Benedetto XV, I-16132 Genoa, Italy

[9] Mashhad Univ Med Sci, Dept Nutr, Fac Med, Mashhad 9177948564, Razavi Khorasan, Iran

[10] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad 9177948564, Razavi Khorasan, Iran

[11] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad 9177948954, Razavi Khorasan, Iran

[12] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad 9177948954, Razavi Khorasan, Iran

来源：

LIFE-BASEL | 2021年 / 11卷 / 12期

关键词：

statins; neuropsychiatric disorders; clinical trials; adverse effects; major depressive disorder; schizophrenia; anxiety; obsessive-compulsive disorder; bipolar disorder; delirium; autism spectrum disorders; MAJOR DEPRESSIVE DISORDER; OBSESSIVE-COMPULSIVE DISORDER; PLACEBO-CONTROLLED TRIAL; SEVERE MENTAL-ILLNESS; DOUBLE-BLIND; BIPOLAR DISORDER; NITRIC-OXIDE; CHOLESTEROL REDUCTION; ADJUNCTIVE TREATMENT; CYTOKINE ALTERATIONS;

D O I：

10.3390/life11121365

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Statins are widely accepted as first-choice agents for the prevention of lipid-related cardiovascular diseases. These drugs have both anti-inflammatory and anti-oxidant properties, which may also make them effective as potential treatment marked by perturbations in these pathways, such as some neuropsychiatric disorders. In this narrative review, we have investigated the effects of statin therapy in individuals suffering from major depressive disorder (MDD), schizophrenia, anxiety, obsessive-compulsive disorder (OCD), bipolar disorder (BD), delirium, and autism spectrum disorders using a broad online search of electronic databases. We also explored the adverse effects of these drugs to obtain insights into the benefits and risks associated with their use in the treatment of these disorders. Lipophilic statins (including simvastatin) because of better brain penetrance may have greater protective effects against MDD and schizophrenia. The significant positive effects of statins in the treatment of anxiety disorders without any serious adverse side effects were shown in numerous studies. In OCD, BD, and delirium, limitations, and contradictions in the available data make it difficult to draw conclusions on any positive effect of statins. The positive effects of simvastatin in autism disorders have been evaluated in only a small number of clinical trials. Although some studies showed positive effect of statins in some neuropsychiatric disorders, further prospective studies are needed to confirm this and define the most effective doses and treatment durations.

引用

页数：23

共 179 条

[21] The neuroinflammatory hypothesis of delirium [J].