Elevated perioperative transaminase level predicts intrahepatic recurrence in hepatitis B-related hepatocellular carcinoma after curative hepatectomy

被引:47
作者
Cheung, Yue-Sun [1 ]
Chan, Henry L. Y. [2 ]
Wong, John [1 ]
Lee, Kit-Fai [1 ]
Poon, Terence C. W. [3 ]
Wong, Nathalie [4 ]
Lai, Paul B. S. [1 ]
机构
[1] Chinese Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Inst Digest Dis, Hong Kong, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
关键词
hepatitis activity; hepatitis B; hepatocellular carcinoma; recurrence; survival;
D O I
10.1016/S1015-9584(08)60056-1
中图分类号
R61 [外科手术学];
学科分类号
摘要
OBJECTIVE: We aimed to evaluate the role of elevated perioperative alanine aminotransferase (ALT) as a surrogate marker of hepatitis activity in determining the risk of recurrence and survival in hepatitis B-related hepatocellular carcinoma (HCC) after curative hepatectomy. METHODS: A retrospective review of the hepatectomy database was performed and 142 patients were found who had hepatitis B-related HCC from January 2001 to March 2006. Their ALT levels preoperatively and 1 month, 3 months, and 6 months postoperatively were recorded. The risk Factors for recurrence and prognostic factors of survival were analysed. RESULTS: An elevated perioperative ALT level (p = 0.021), multiple tumour nodules in the resected specimen (p < 0.001), and a tumour size greater than 5 cm (p = 0.001) were significant independent risk factors for tumour recurrence. The latter two factors were also independent prognostic factors for overall survival and disease-free survival. An elevated ALT level was an independent prognostic factor for disease-free survival (p = 0.025). CONCLUSION: An elevated perioperative ALT level, which reflects increased hepatitis activity, is an independent risk factor for intrahepatic recurrence of hepatitis B-related HCC. It is also associated with a poorer disease-free survival rate.
引用
收藏
页码:41 / 49
页数:9
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