The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

被引：13

作者：

Szatkiewicz, Jin ^{[1
]}

Crowley, James J. ^{[1
]}

Adolfsson, Annelie Nordin ^{[2
]}

Aberg, Karolina A. ^{[3
]}

Alaerts, Maaike ^{[4
,5
]}

Genovese, Giulio ^{[6
]}

McCarroll, Steven ^{[6
]}

Del-Favero, Jurgen ^{[7
,8
]}

Adolfsson, Rolf ^{[2
]}

Sullivan, Patrick F. ^{[1
,9
,10
]}

机构：

[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA

[2] Univ Umea, Dept Clin Sci & Psychiat, Umea, Sweden

[3] Virginia Commonwealth Univ, Ctr Biomarker Res & Precis Med, Richmond, VA USA

[4] Univ Antwerp, Ctr Med Genet, Antwerp, Belgium

[5] Antwerp Univ Hosp, Antwerp, Belgium

[6] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[7] VIB Ctr Mol Neurol, Univ Pl 1, Antwerp, Belgium

[8] Multiplicom NV, Galileilaan 18, Niel, Belgium

[9] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA

[10] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

来源：

TRANSLATIONAL PSYCHIATRY | 2019年 / 9卷 / 1期

基金：

瑞典研究理事会;

关键词：

COPY NUMBER VARIATION; BIPOLAR DISORDER; ASSOCIATION; SCHIZOPHRENIA; INTERVIEW;

D O I：

10.1038/s41398-019-0414-9

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.

引用

页数：8

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