The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

被引：13
作者：
Szatkiewicz, Jin [1 ]
Crowley, James J. [1 ]
Adolfsson, Annelie Nordin [2 ]
Aberg, Karolina A. [3 ]
Alaerts, Maaike [4 ,5 ]
Genovese, Giulio [6 ]
McCarroll, Steven [6 ]
Del-Favero, Jurgen [7 ,8 ]
Adolfsson, Rolf [2 ]
Sullivan, Patrick F. [1 ,9 ,10 ]
机构：
[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA
[2] Univ Umea, Dept Clin Sci & Psychiat, Umea, Sweden
[3] Virginia Commonwealth Univ, Ctr Biomarker Res & Precis Med, Richmond, VA USA
[4] Univ Antwerp, Ctr Med Genet, Antwerp, Belgium
[5] Antwerp Univ Hosp, Antwerp, Belgium
[6] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
[7] VIB Ctr Mol Neurol, Univ Pl 1, Antwerp, Belgium
[8] Multiplicom NV, Galileilaan 18, Niel, Belgium
[9] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA
[10] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
来源：
TRANSLATIONAL PSYCHIATRY | 2019年 / 9卷 / 1期
基金：
瑞典研究理事会;
关键词：
COPY NUMBER VARIATION; BIPOLAR DISORDER; ASSOCIATION; SCHIZOPHRENIA; INTERVIEW;
D O I：
10.1038/s41398-019-0414-9
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.
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页数：8
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