Comparative evaluation of microcapsules prepared by fluidization atomization and melt coating process

被引：6

作者：

Racz, I ^{[1
]}

Dredan, J ^{[1
]}

Antal, I ^{[1
]}

Gondar, E ^{[1
]}

机构：

[1] RICHTER GEDEON PHARMACEUT WORKS,BUDAPEST,HUNGARY

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1997年 / 23卷 / 06期

关键词：

D O I：

10.3109/03639049709149823

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Microcapsules were prepared from potassium chloride as a highly water-soluble model drug, and coated with white beeswax by the fluidization and melt methods. Dissolution profiles, microscopic surface topography, and diffusion reflectance spectra of microcapsules were evaluated by comparative studies. The results show remarkable differences in the examined parameters of the microcapsules prepared by different techniques. The results demonstrate that melt coating is able to control the drug release and may serve as an advantageous solvent-free alternative of fluidization.

引用

页码：583 / 587

页数：5

共 12 条

[1] FORMULATION AND INVITRO-INVIVO CHARACTERIZATION OF SOLID DISPERSIONS OF PIROXICAM [J].