Genes Against Aging

被引：18
作者：
Miller, Richard A. [1 ,2 ]
机构：
[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Geriatr Ctr, Ann Arbor, MI 48109 USA
来源：
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2012年 / 67卷 / 05期
关键词：
Longevity; Mice; Genetics; Comparative biology; LIFE-SPAN; MUTANT MICE; DWARF MICE; HEIGHT; LONGEVITY; MORTALITY; RESISTANT; CANCER; FIBROBLASTS; GERONTOLOGY;
D O I：
10.1093/gerona/gls082
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Individual mutations in mice can slow aging: They extend life span by retarding a wide range of harmful, age-dependent changes in multiple cells and tissues. Evolutionary changes-by definition, changes in DNA sequence-can lead to even more dramatic postponement of age-dependent deterioration. Genetic variation within a species, for example among breeds of dogs, can also lead to major changes in aging rate, although there is not yet any strong evidence for similar genetic variation that modulates aging in rodents or humans. This essay compares different strategies for using genetic information to clarify questions in biogerontology, suggesting an emphasis on genes that can retard multiple forms of age-dependent dysfunction in parallel.
引用
收藏
页码：495 / 502
页数：8
相关论文
共 51 条
  • [1] ALBANES D, 1988, CANCER RES, V48, P1658
  • [2] RETARDED SENESCENCE IN AN INSULAR POPULATION OF VIRGINIA OPOSSUMS (DIDELPHIS-VIRGINIANA)
    AUSTAD, SN
    [J]. JOURNAL OF ZOOLOGY, 1993, 229 : 695 - 708
  • [3] HEIGHT AND MORTALITY IN THE COUNTIES OF ENGLAND AND WALES
    BARKER, DJP
    OSMOND, C
    GOLDING, J
    [J]. ANNALS OF HUMAN BIOLOGY, 1990, 17 (01) : 1 - 6
  • [4] Contemporary human genetic strategies in aging research
    Bloss, Cinnamon S.
    Pawlikowska, Ludmila
    Schork, Nicholas J.
    [J]. AGEING RESEARCH REVIEWS, 2011, 10 (02) : 191 - 200
  • [5] Extended longevity in mice lacking the insulin receptor in adipose tissue
    Blüher, M
    Kahn, BB
    Kahn, CR
    [J]. SCIENCE, 2003, 299 (5606) : 572 - 574
  • [6] Mortality in over 350,000 insured Swedish dogs from 1995-2000:: I.: Breed-, gender-, age- and cause-specific rates
    Bonnett, BN
    Egenvall, A
    Hedhammar, Å
    Olson, P
    [J]. ACTA VETERINARIA SCANDINAVICA, 2005, 46 (03) : 105 - 120
  • [7] Demographic and clinical characteristics of geriatric horses: 467 cases (1989-1999)
    Brosnahan, MM
    Paradis, MR
    [J]. JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2003, 223 (01): : 93 - 98
  • [8] Dwarf mice and the ageing process
    BrownBorg, HM
    Borg, KE
    Meliska, CJ
    Bartke, A
    [J]. NATURE, 1996, 384 (6604) : 33 - 33
  • [9] Mitochondrially encoded methionine is inversely related to longevity in mammals
    Carlos Aledo, Juan
    Li, Yang
    Pedro de Magalhaes, Joao
    Ruiz-Camacho, Manuel
    Antonio Perez-Claros, Juan
    [J]. AGING CELL, 2011, 10 (02) : 198 - 207
  • [10] Charlesworth B, 1994, EVOLUTION AGE STRUCT
123456