An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction

被引：90

作者：

Iwabuchi, Y ^{[1
]}

Sugihara, T ^{[1
]}

Esumi, T ^{[1
]}

Hatakeyama, S ^{[1
]}

机构：

[1] Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 44期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4039(01)01676-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantio- and stereocontrolled route to epopromycin B having the epoxy-beta -aminoketone pharmacophore is developed based on the cinchona alkaloid-catalyzed Baylis-Hillman reaction of N-Fmoc-leucinal. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7867 / 7871

页数：5

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