Canine specific ELISA for coagulation factor VII

被引：4

作者：

Knudsen, Tom ^{[1
,2
]}

Kjelgaard-Hansen, Mads ^{[1
]}

Tranholm, Mikael ^{[2
]}

Wiinberg, Bo ^{[1
]}

Clausen, Jes T. ^{[2
]}

Hansen, Jens Jacob ^{[2
]}

Nichols, Timothy C. ^{[3
]}

Kjalke, Marianne ^{[2
]}

Jensen, Asger L. ^{[4
]}

Kristensen, Annemarie T. ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Small Anim Clin Sci, Fac Life Sci, DK-1870 Copenhagen, Denmark

[2] Novo Nordisk AS, DK-2760 Malov, Denmark

[3] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27516 USA

[4] Univ Copenhagen, Dept Basic Anim & Vet Sci, Fac Life Sci, DK-1870 Frederiksberg C, Denmark

来源：

VETERINARY JOURNAL | 2011年 / 190卷 / 03期

关键词：

FVII deficiency; Haemostasis; Coagulation factor; ELISA; Plasma; Immunoassays; TISSUE FACTOR; PROTHROMBIN TIME; CLINICAL-ASPECTS; DEFICIENCY; PLASMA; BEAGLE;

D O I：

10.1016/j.tvjl.2010.11.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Canine coagulation factor VII (FVII) deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated. FVII procoagulant activity can be measured by FVII activity (FVII:C), but assays for measurement of canine specific FVII antigen (FVII:Ag) have not been available to date. In this study, a canine specific ELISA for measurement of FVII:Ag in plasma was developed and validated. The FVII:Ag ELISA correctly diagnosed homozygous and heterozygous hereditary FVII deficiency. Together with activity based assays, such as FVII:C, the FVII:Ag ELISA should be valuable in the diagnosis of hereditary canine FVII deficiency. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：352 / 358

页数：7

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