TREATMENT OF LOCALLY ADVANCED PANCREATIC CANCER: THE ROLE OF RADIATION THERAPY

被引：28

作者：

Johung, Klmberly ^{[1
]}

Saif, Muhammad Wasif ^{[2
,3
]}

Chang, Bryan W. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06520 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY USA

[3] Presbyterian Hosp, Pancreas Ctr, New York, NY USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2012年 / 82卷 / 02期

关键词：

Pancreatic cancer; Radiotherapy; FULL-DOSE GEMCITABINE; PHASE-II TRIAL; CONCURRENT RADIOTHERAPY; CONSOLIDATIVE CHEMORADIATION; UNRESECTABLE ADENOCARCINOMA; STEREOTACTIC RADIOSURGERY; MAINTENANCE GEMCITABINE; 5-FLUOROURACIL INFUSION; ONCOLOGY-GROUP; CHEMOTHERAPY;

D O I：

10.1016/j.ijrobp.2011.08.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer remains associated with an extremely poor prognosis. Surgical resection can be curative, but the majority of patients present with locally advanced or metastatic disease. Treatment for patients with locally advanced disease is controversial. Therapeutic options include systemic therapy alone, concurrent chemoradiation, or induction chemotherapy followed by chemoradiation. We review the evidence to date regarding the treatment of locally advanced pancreatic cancer (LAPC), as well as evolving strategies including the emerging role of targeted therapies. We propose that if radiation is used for patients with LAPC, it should be delivered with concurrent chemotherapy and following a period of induction chemotherapy. (C) 2012 Elsevier Inc.

引用

页码：508 / 518

页数：11

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