Cigarette smoking is associated with acrylamide exposure among the US population: NHANES 2011-2016

被引:15
作者
Kenwood, Brandon M. [1 ,2 ]
Zhu, Wanzhe [1 ]
Zhang, Luyu [1 ]
Bhandari, Deepak [1 ]
Blount, Benjamin C. [1 ]
机构
[1] Centers Dis Control & Prevent, Natl Ctr Environm Hlth, Div Lab Sci, Tobacco & Volatiles Branch, Atlanta, GA 30341 USA
[2] Centers Dis Control & Prevent, Div Lab Sci, Tobacco & Volatiles Branch, MS S103-3,4770 Buford Highway, Atlanta, GA 30341 USA
关键词
2-Carbamoylethyl mercapturic acid (2CaEMA); AAMA; GAMA; Acrylamide; Tobacco smoke; The national health and nutrition examination survey (NHANES); DIETARY ACRYLAMIDE; URINARY METABOLITES; MERCAPTURIC ACIDS; HEMOGLOBIN ADDUCTS; INTERNAL EXPOSURE; BIOMARKERS; RATS; TOXICOKINETICS; NUTRITION; HUMANS;
D O I
10.1016/j.envres.2022.112774
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
2-carbamoylethyl mercapturic acid (2CaEMA, N-Acetyl-S-carbamoylethyl-L-cysteine) is a urinary metabolite and exposure biomarker of acrylamide, which is a harmful volatile organic compound found in cigarette smoke and in some foods. The goal of this study was to determine the association between cigarette smoking and urinary 2CaEMA concentrations among the U.S. population while considering potential dietary sources of acrylamide intake and demographics. We measured 2CaEMA concentrations in urine specimens collected during the National Health and Nutrition Examination Survey 2011-2012, 2013-2014, and 2015-2016 cycles from eligible participants 18 years and older (n = 5443) using liquid chromatography/tandem mass spectrometry. We developed multiple regression models with urinary 2CaEMA concentrations as the dependent variable and sex, age, race/Hispanic origin, reported primary sources of dietary acrylamide intake, and cigarette smoke exposure as independent variables. This study demonstrates that cigarette smoking is strongly associated with urinary 2CaEMA, suggests that cigarette smoking is likely a primary source of acrylamide exposure, and provides a baseline measure for 2CaEMA in the U.S. population.
引用
收藏
页数:6
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