Role of T Cells in Type 2 Diabetic Nephropathy

被引：69

作者：

Wu, Chia-Chao ^{[2
,3
]}

Sytwu, Huey-Kang ^{[3
]}

Lu, Kuo-Cheng ^{[1
]}

Lin, Yuh-Feng ^{[2
,4
]}

机构：

[1] Fu Jen Catholic Univ, Sch Med, Cardinal Tien Hosp, Dept Med, New Taipei City 231, Taiwan

[2] Tri Serv Gen Hosp, Natl Def Med Ctr, Div Nephrol, Dept Med, Taipei 114, Taiwan

[3] Natl Def Med Ctr, Grad Inst Microbiol & Immunol, Taipei 114, Taiwan

[4] Taipei Med Univ, Shuang Ho Hosp, Dept Med, Div Nephrol, Taipei 110, Taiwan

来源：

EXPERIMENTAL DIABETES RESEARCH | 2011年

关键词：

MONOCYTE CHEMOATTRACTANT PROTEIN-1; ADIPOSE-TISSUE INFLAMMATION; GLYCATION END-PRODUCTS; RENAL INJURY; INSULIN-RESISTANCE; METABOLIC SYNDROME; COSTIMULATORY MOLECULES; ENDOTHELIAL DYSFUNCTION; CHEMOKINE RECEPTORS; AUTOIMMUNE-DISEASE;

D O I：

10.1155/2011/514738

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetic nephropathy (DN) is the most common cause of end-stage renal disease and is increasingly considered as an inflammatory disease characterized by leukocyte infiltration at every stage of renal involvement. Inflammation and activation of the immune system are closely involved in the pathogenesis of diabetes and its microvascular complications. Macrophage has been well recognized to play an important role in type 2 DN, leukocyte infiltration, and participated in process of DN, as was proposed recently. Th1, Th2, Th17, T reg, and cytotoxic T cells are involved in the development and progression of DN. The purpose of this review is to assemble current information concerning the role of T cells in the development and progression of type 2 DN. Specific emphasis is placed on the potential interaction and contribution of the T cells to renal damage. The therapeutic strategies involving T cells in the treatment of type 2 DN are also reviewed. Improving knowledge of the recognition of T cells as significant pathogenic mediators in DN reinforces the possibility of new potential therapeutic targets translated into future clinical treatments.

引用

页数：9

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