Chiral separation by counter-current chromatography

被引:49
作者
Huang, Xin-Yi
Di, Duo-Long [1 ]
机构
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 73000, Peoples R China
基金
中国国家自然科学基金;
关键词
Biphasic chiral recognition; Chiral chromatography; Chiral selector; Chiral separation; Counter-current chromatography; Liquid-liquid partition; Multiple dual-mode elution; Recycling elution mode; Separation efficiency; Solvent system; HYDROXYPROPYL-BETA-CYCLODEXTRIN; CENTRIFUGAL PARTITION CHROMATOGRAPHY; PREPARATIVE ENANTIOSEPARATION; ACID ENANTIOMERS; L-(+)-TARTARIC ACID; PHENYLSUCCINIC ACID; AROMATIC-ACIDS; L-TARTRATE; SELECTOR; RESOLUTION;
D O I
10.1016/j.trac.2015.01.009
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Counter-current chromatography (CCC) is a new, efficient, productive chromatographic technique based on continuous liquid-liquid partition. Recently, it attracted more attention in chiral separation due to its high load capacity, cheap liquid stationary phase and low solvent consumption, when compared to traditional chiral separation techniques. This review presents advances and applications of chiral separation using high-speed CCC in recent years. We summarize the major benefits and the limitations of chiral separation by CCC. We introduce in detail some novel methods, which can improve the resolution of enantiomers and are easily achieved on classical CCC apparatus. We also outline challenges and future perspectives in developing chiral separation by CCC. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:128 / 133
页数:6
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