Selective Palladium-Catalyzed C-F Activation/Carbon-Carbon Bond Formation of Polyfluoroaryl Oxazolines

被引：71

作者：

Yu, Daohong ^{[1
]}

Shen, Qilong ^{[1
]}

Lu, Long ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chfigemistry, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 04期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; H BONDS; GRIGNARD-REAGENTS; ARYL FLUORIDES; NICKEL; DERIVATIVES; HALIDES;

D O I：

10.1021/jo2023262

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A selective palladium-catalyzed Suzuki-Miyaura coupling reaction of polyfluorophenyl oxazolines through ortho C-F activation is described. It was found that reactions with DPPF as the ligand occurred much faster than those with other ligands. A variety of arylboronic acids including challenging functionalized arylboronic acids such as enolizable ketones, aldehyde, cyano, ester, and trifluoromethyl groups were tolerated with the reaction conditions.

引用

页码：1798 / 1804

页数：7

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