The immune landscape of myelodysplastic syndromes

被引：32

作者：

Fozza, Claudio ^{[1
]}

Crobu, Valeria ^{[1
]}

Isoni, Maria Antonia ^{[1
]}

Dore, Fausto ^{[1
]}

机构：

[1] Univ Sassari, Dept Clin & Expt Med, Viale San Pietro 12, I-07100 Sassari, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2016年 / 107卷

关键词：

Myelodysplastic syndromes; Autoimmunity; T-cells; Immunomodulating therapies; TUMOR-NECROSIS-FACTOR; STEM-CELL TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; REGULATORY T-CELLS; BONE-MARROW; DENDRITIC CELLS; ANTITHYMOCYTE GLOBULIN; FACTOR-ALPHA; IMMUNOLOGICAL ABNORMALITIES; REFRACTORY-ANEMIA;

D O I：

10.1016/j.critrevonc.2016.08.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Even though the pathogenesis of myelodysplastic syndromes (MDS) is dominated by specific molecular defects involving hematopoietic precursors, also immune mechanisms seem to play a fundamental functional role. In this review we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus on studies addressing the possible influence of different immune cell subpopulations on the disease onset and evolution. We will finally consider therapeutic approaches based on immunomodulation, ranging from immunosuppressants to vaccination and transplantation strategies. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：90 / 99

页数：10

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