Expression of vascular endothelial growth factor and basic fibroblast growth factor in extramammary Paget disease

被引：1

作者：

Xu, Xiaoyun ^{[1
]}

Shao, Ning ^{[2
]}

Qiao, Di ^{[3
]}

Wang, Zengjun ^{[4
]}

Song, Ningjing ^{[5
]}

Song, Ninghong ^{[4
]}

机构：

[1] Jiangsu Prov Geriatr Hosp, Dept Dermatol, Nanjing 210024, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Peoples Hosp Wuxi 2, Wuxi 214002, Peoples R China

[3] Jiangsu Prov Geriatr Hosp, Dept Urol, Nanjing 210024, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing 210029, Jiangsu, Peoples R China

[5] Shanghai Inst Dermatol, Dept Dermatol, Shanghai 200050, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 03期

关键词：

Extramammary Paget disease; VEGF; bFGF; TRANSCRIPTION FACTOR SP1; GLANS-PENIS; CELL CARCINOMA; CANCER; ANGIOGENESIS; VEGF; BFGF; SECONDARY; MAMMARY; IMPACT;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extramammary Paget's disease (EMPD) is a special type of cancers. The etiology of the disease is still unclear. We aimed to study the expression differences of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in EMPD tissues and corresponding adjacent normal tissues. The mRNA expression was detected by RT-PCR and the protein expression was explored by immunohistochemistry. Higher immunostaining signal scores of bFGF and VEGF in EMPD tissues had been found (z = -3.827, P < 0.001, z = -3.729, P < 0.001, respectively). In addition, the mRNA expression of bFGF and VEGF was higher in EMPD tissues, which had been validated by RT-PCR (t = 5.771, P < 0.001, t = 3.304, P = 0.004, respectively). The VEGF and bFGF might be the key signaling proteins in angiogenesis of EMPD. How to block the VEGF and bFGF in EMPD and to destroy the blood supply of the tumor cells becomes the focus of our future research.

引用

页码：3062 / 3068

页数：7

共 26 条

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