The bZIP Proteins of Oncogenic Viruses

被引：10
作者：
Stolz, Madeleine L. [1 ]
McCormick, Craig [1 ]
机构：
[1] Dalhousie Univ, Dept Microbiol & Immunol, 5850 Coll St, Halifax, NS B3H 4R2, Canada
来源：
VIRUSES-BASEL | 2020年 / 12卷 / 07期
关键词：
basic leucine zipper (bZIP); herpesvirus; Marek's disease virus (MDV); Epstein-Barr virus (EBV); Kaposi's sarcoma-associated herpesvirus (KSHV); human T-cell leukemia virus (HTLV); hepatitis C virus (HCV); EPSTEIN-BARR-VIRUS; HEPATITIS-C VIRUS; CCAAT/ENHANCER-BINDING-PROTEIN; HERPESVIRUS K-BZIP; CELL-CYCLE ARREST; ENDOPLASMIC-RETICULUM STRESS; REPLICATION-ASSOCIATED PROTEIN; FAMILY TRANSCRIPTION FACTOR; LEUCINE-ZIPPER FACTOR; ENCODED MEQ PROTEIN;
D O I：
10.3390/v12070757
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Basic leucine zipper (bZIP) transcription factors (TFs) govern diverse cellular processes and cell fate decisions. The hallmark of the leucine zipper domain is the heptad repeat, with leucine residues at every seventh position in the domain. These leucine residues enable homo- and heterodimerization between ZIP domain alpha-helices, generating coiled-coil structures that stabilize interactions between adjacent DNA-binding domains and target DNA substrates. Several cancer-causing viruses encode viral bZIP TFs, including human T-cell leukemia virus (HTLV), hepatitis C virus (HCV) and the herpesviruses Marek's disease virus (MDV), Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). Here, we provide a comprehensive review of these viral bZIP TFs and their impact on viral replication, host cell responses and cell fate.
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页数：33
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  • [1] Experimental identification of homodimerizing B-ZIP families in Homo sapiens
    Acharya, Asha
    Rishi, Vikas
    Moll, Jonathan
    Vinson, Charles
    [J]. JOURNAL OF STRUCTURAL BIOLOGY, 2006, 155 (02) : 130 - 139
  • [2] The Epstein-Barr virus BZLF1 protein interacts physically and functionally with the histone acetylase CREB-binding protein
    Adamson, AL
    Kenney, S
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (08) : 6551 - 6558
  • [3] Formation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B protein
    Aligo, Jason
    Jia, Shuaizheng
    Manna, David
    Konan, Kouacou V.
    [J]. VIROLOGY, 2009, 393 (01) : 68 - 83
  • [4] The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas
    Alonso, Ines Garces de los Fayos
    Liang, Huan-Chang
    Turner, Suzanne D.
    Lagger, Sabine
    Merkel, Olaf
    Kenner, Lukas
    [J]. CANCERS, 2018, 10 (04)
  • [5] Reactivation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus: An Update
    Aneja, Kawalpreet K.
    Yuan, Yan
    [J]. FRONTIERS IN MICROBIOLOGY, 2017, 8
  • [6] Nuclear localization and dynamic properties of the Marek's disease virus oncogene products Meq and Meq/vIL8
    Anobile, JM
    Arumugaswami, V
    Downs, D
    Czymmek, K
    Parcells, M
    Schmidt, CJ
    [J]. JOURNAL OF VIROLOGY, 2006, 80 (03) : 1160 - 1166
  • [7] Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation
    Arnold, Joshua
    Zimmerman, Bevin
    Li, Min
    Lairmore, Michael D.
    Green, Patrick L.
    [J]. BLOOD, 2008, 112 (09) : 3788 - 3797
  • [8] Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP)
    AuCoin, DP
    Colletti, KS
    Cei, SA
    Papousková, I
    Tarrant, M
    Pari, GS
    [J]. VIROLOGY, 2004, 318 (02) : 542 - 555
  • [9] Functional Interaction between Epstein-Barr Virus Replication Protein Zta and Host DNA Damage Response Protein 53BP1
    Bailey, Sarah G.
    Verrall, Elizabeth
    Schelcher, Celine
    Rhie, Alex
    Doherty, Aidan J.
    Sinclair, Alison J.
    [J]. JOURNAL OF VIROLOGY, 2009, 83 (21) : 11116 - 11122
  • [10] Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
    Baratella, Marco
    Forlani, Greta
    Raval, Goutham U.
    Tedeschi, Alessandra
    Gout, Olivier
    Gessain, Antoine
    Tosi, Giovanna
    Accolla, Roberto S.
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2017, 11 (01):
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