Sjogren's syndrome: from pathogenesis to novel therapeutic targets

被引：0
作者：
Barone, F. [1 ]
Colafrancesco, S. [1 ,2 ]
机构：
[1] Univ Birmingham, Ctr Translat Inflammat Res, Inst Inflammat & Ageing, Birmingham B15 2TT, W Midlands, England
[2] Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Unit, Rome, Italy
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2016年 / 34卷 / 04期
基金：
英国医学研究理事会;
关键词：
primary Sjogren's syndrome; biologics; TLOs; stromal cells; chemokines; cytokines; FIBROBLASTIC RETICULAR CELLS; TUMOR-NECROSIS-FACTOR; QUALITY-OF-LIFE; LYMPH-NODE; SALIVARY-GLANDS; B-CELLS; MALIGNANT-LYMPHOMA; CIRCULATING LEVELS; GERMINAL-CENTERS; MALT LYMPHOMA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Primary Sjogren's syndrome (pSS) is a chronic inflammatory autoimmune disease, characterised by a chronic infiltration of exocrine glands, mainly salivary glands, with the histological features of focal lymphocytic sialoadenitis. Disease spectrum is broad and the occurrence of several extra-glandular manifestations, and in rare cases lymphoma development, is well known. A specific approved treatment for pSS is still lacking and the detection of novel therapeutic biologic target is ongoing. The identification of biological fingerprints seems essential in order to stratify patients both in clinical trials and in real life. Discovery of new components of the inflammatory response will be the key in the future for the identification of novel additional therapeutic options.
引用
收藏
页码：S58 / S62
页数：5
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