Gonadotropin-releasing hormone;
Delayed puberty;
Hypogonadism;
FOLLICLE-STIMULATING-HORMONE;
HUMAN CHORIONIC-GONADOTROPIN;
EARLY POSTNATAL TREATMENT;
RECOMBINANT HUMAN FSH;
SERTOLI-CELL;
UNDESCENDED TESTES;
KALLMANN-SYNDROME;
INHIBIN-B;
NONOBSTRUCTIVE AZOOSPERMIA;
MENOPAUSAL GONADOTROPIN;
D O I:
暂无
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
The phenomenon known as "mini-puberty" refers to activation of the neonatal hypothalamo-pituitary axis causing serum concentrations of gonadotrophins and testosterone (T) to approach adult male levels. This early neonatal period is a key proliferative window for testicular germ cells and immature Sertoli cells. Although failure to spontaneously initiate (adolescent) puberty is the most evident consequence of a defective gonadotropin-releasing hormone (GnRH) neurosecretory network, absent mini-puberty is also likely to have a major impact on the reproductive phenotype of men with congenital hypogonadotrophic hypogonadism (CHH). Furthermore, the phase of male mini-puberty represents a key window-of opportunity to identify congenital GnRH deficiency (either isolated CHH, or as part of combined pituitary hormone deficiency) in childhood. Among male neonates exhibiting "red flag" indicators for CHH (i.e. maldescended testes with or without cryptorchidism) a single serum sample (between 4-8 weeks of life) can pinpoint congenital GnRH deficiency far more rapidly and with much greater accuracy than dynamic tests performed in later childhood or adolescence. Potential consequences for missing absent mini-puberty in a male neonate include the lack of monitoring of pubertal progression/lack of progression, and the missed opportunity for early therapeutic intervention. This article will review our current understanding of the mechanisms and clinical consequences of mini-puberty. Furthermore, evidence for the optimal clinical management of patients with absent mini-puberty will be discussed.
机构:
Southampton Gen Hosp, Div Women & Children, Dept Paediat Urol, Care Grp Child Hlth MP43, Southampton SO16 6YD, Hants, EnglandSouthampton Gen Hosp, Div Women & Children, Dept Paediat Urol, Care Grp Child Hlth MP43, Southampton SO16 6YD, Hants, England
Biers, S. M.
;
Malone, P. S.
论文数: 0引用数: 0
h-index: 0
机构:
Southampton Gen Hosp, Div Women & Children, Dept Paediat Urol, Care Grp Child Hlth MP43, Southampton SO16 6YD, Hants, EnglandSouthampton Gen Hosp, Div Women & Children, Dept Paediat Urol, Care Grp Child Hlth MP43, Southampton SO16 6YD, Hants, England
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Boepple, Paul A.
;
Hayes, Frances J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Hayes, Frances J.
;
Dwyer, Andrew A.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Dwyer, Andrew A.
;
Raivio, Taneli
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Raivio, Taneli
;
Lee, Hang
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Biostat, Boston, MA 02114 USA
Massachusetts Gen Hosp, Gen Clin Res Ctr, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Lee, Hang
;
Crowley, William F., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Crowley, William F., Jr.
;
Pitteloud, Nelly
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
机构:
Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Bougneres, P.
;
Francois, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Francois, M.
;
Pantalone, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Pantalone, L.
;
Rodrigue, D.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Rodrigue, D.
;
Bouvattier, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Bouvattier, C.
;
Demesteere, E.
论文数: 0引用数: 0
h-index: 0
机构:
Serono France, F-92658 Boulogne, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Demesteere, E.
;
Roger, D.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Roger, D.
;
Lahlou, N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop St Vincent de Paul, Pediat Hormone Lab, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
机构:
Univ Paris Sud, Hop Bicetre, Dept Pediat Endocrinienne, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Bouvattier, Claire
;
Maione, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Maione, Luigi
;
Bouligand, Jerome
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Sud, Hop Bicetre, Serv Genet Mol Pharmacogenet & Hormonol, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Bouligand, Jerome
;
Dode, Catherine
论文数: 0引用数: 0
h-index: 0
机构:
Inst Cochin, Dept Genet & Dev, F-75679 Paris 14, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Dode, Catherine
;
Guiochon-Mantel, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Sud, Hop Bicetre, Serv Genet Mol Pharmacogenet & Hormonol, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Guiochon-Mantel, Anne
;
Young, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
机构:
Southampton Gen Hosp, Div Women & Children, Dept Paediat Urol, Care Grp Child Hlth MP43, Southampton SO16 6YD, Hants, EnglandSouthampton Gen Hosp, Div Women & Children, Dept Paediat Urol, Care Grp Child Hlth MP43, Southampton SO16 6YD, Hants, England
Biers, S. M.
;
Malone, P. S.
论文数: 0引用数: 0
h-index: 0
机构:
Southampton Gen Hosp, Div Women & Children, Dept Paediat Urol, Care Grp Child Hlth MP43, Southampton SO16 6YD, Hants, EnglandSouthampton Gen Hosp, Div Women & Children, Dept Paediat Urol, Care Grp Child Hlth MP43, Southampton SO16 6YD, Hants, England
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Boepple, Paul A.
;
Hayes, Frances J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Hayes, Frances J.
;
Dwyer, Andrew A.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Dwyer, Andrew A.
;
Raivio, Taneli
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Raivio, Taneli
;
Lee, Hang
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Biostat, Boston, MA 02114 USA
Massachusetts Gen Hosp, Gen Clin Res Ctr, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Lee, Hang
;
Crowley, William F., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
Crowley, William F., Jr.
;
Pitteloud, Nelly
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Med, Reprod Endocrine Unit, Boston, MA 02114 USA
机构:
Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Bougneres, P.
;
Francois, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Francois, M.
;
Pantalone, L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Pantalone, L.
;
Rodrigue, D.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Rodrigue, D.
;
Bouvattier, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Bouvattier, C.
;
Demesteere, E.
论文数: 0引用数: 0
h-index: 0
机构:
Serono France, F-92658 Boulogne, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Demesteere, E.
;
Roger, D.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
Roger, D.
;
Lahlou, N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Hop St Vincent de Paul, Pediat Hormone Lab, F-75014 Paris, FranceUniv Paris 05, Hop St Vincent de Paul, Dept Pediat Enocrinol, F-75014 Paris, France
机构:
Univ Paris Sud, Hop Bicetre, Dept Pediat Endocrinienne, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Bouvattier, Claire
;
Maione, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Maione, Luigi
;
Bouligand, Jerome
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Sud, Hop Bicetre, Serv Genet Mol Pharmacogenet & Hormonol, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Bouligand, Jerome
;
Dode, Catherine
论文数: 0引用数: 0
h-index: 0
机构:
Inst Cochin, Dept Genet & Dev, F-75679 Paris 14, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Dode, Catherine
;
Guiochon-Mantel, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Sud, Hop Bicetre, Serv Genet Mol Pharmacogenet & Hormonol, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France
Guiochon-Mantel, Anne
;
Young, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, FranceUniv Paris Sud, Hop Bicetre, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France