Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project

被引：12

作者：

Benet, Marta ^{[1
,2
,3
]}

Albang, Richard ^{[4
]}

Pinart, Mariona ^{[1
,2
,3
,5
]}

Hohmann, Cynthia ^{[6
]}

Tischer, Christina G. ^{[1
,2
,3
]}

Annesi-Maesano, Isabella ^{[7
,8
]}

Baiz, Nour ^{[7
,8
]}

Bindslev-Jensen, Carsten ^{[9
]}

Lodrup Carlsen, Karin C. ^{[10
,11
]}

Carlsen, Kai-Hakon ^{[10
,11
]}

Cirugeda, Lourdes ^{[1
,2
,3
]}

Eller, Esben ^{[9
]}

Fantini, Maria Pia ^{[12
]}

Gehring, Ulrike ^{[13
]}

Gerhard, Beatrix ^{[4
]}

Gori, Davide ^{[12
]}

Hallner, Eva ^{[14
,15
]}

Kull, Inger ^{[16
,17
]}

Lenzi, Jacopo ^{[12
]}

McEachan, Rosemary ^{[18
]}

Minina, Eleonora ^{[4
]}

Momas, Isabelle ^{[19
,20
]}

Narduzzi, Silvia ^{[21
]}

Petherick, Emily S. ^{[22
]}

Porta, Daniela ^{[21
]}

Ranciere, Fanny ^{[19
]}

Standl, Marie ^{[23
]}

Torrent, Maties ^{[3
,24
]}

Wijga, Alet H. ^{[25
]}

Wright, John ^{[18
]}

Kogevinas, Manolis ^{[1
,2
,3
,5
,26
]}

Guerra, Stefano ^{[1
,2
,3
,27
]}

Sunyer, Jordi ^{[1
,2
,3
,5
]}

Keil, Thomas ^{[6
]}

Bousquet, Jean ^{[28
,29
]}

Maier, Dieter ^{[4
]}

Anto, Josep M. ^{[1
,2
,3
,5
]}

Garcia-Aymerich, Judith ^{[1
,2
,3
]}

机构：

[1] ISGlobal Barcelona Inst Global Hlth, Doctor Aiguader 88, Barcelona 08003, Spain

[2] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain

[3] Consorcio Ctr Invest Biomed Red Epidemiol & Salud, Barcelona, Spain

[4] Biomax Informat AG, Planegg, Germany

[5] Hosp del Mar, Res Inst, Barcelona, Spain

[6] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany

[7] INSERM, Inst Pierre Louis Epidemiol & Sante Publ, Epidemiol Allerg & Resp Dis Dept, Paris, France

[8] Univ Paris 06, St Antoine Med Sch, Paris, France

[9] Odense Univ Hosp, Dept Dermatol & Allergy Ctr, Odense Res Ctr Anaphylaxis, Odense, Denmark

[10] Univ Oslo, Div Paediat & Adolescent Med, Dept Paediat Allergy & Pulmonol, Fac Med, Oslo, Norway

[11] Oslo Univ Hosp, Oslo, Norway

[12] Alma Mater Studiorum Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy

[13] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[14] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[15] Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden

[16] South Gen Hosp Stockholm, Sachs Children & Youth Hosp, Stockholm, Sweden

[17] Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden

[18] Bradford Teaching Hosp NHS Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England

[19] Univ Paris 05, Sorbonne Paris Cite, EA 4064, Epidemiol Environm, Paris, France

[20] Cellule Cohorte, Mairie Paris Direct Act Sociale Enfance & Sante, Paris, France

[21] Lazio Reg Hlth Serv, Dept Epidemiol, Rome, Italy

[22] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England

[23] Helmholtz Zentrum Munchen German Res Ctr Environm, Inst Epidemiol 1, Neuherberg, Germany

[24] Serv Salut Ies Illes Balears, Area Salut Menorca, Spain

[25] Natl Inst Publ Hlth & Environm, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands

[26] Natl Sch Publ Hlth, Athens, Greece

[27] Univ Arizona, Asthma & Airway Dis Res Ctr, Tucson, AZ USA

[28] European Innovat Partnership Act & Hlyh Ageing, Malad Chron Vieillissement Actif France, Montpellier, France

[29] INSERM, UMR 1168, Aging & Chron Dis Epidemiol & Publ Hlth Approache, Villejuif, France

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2019年 / 188卷 / 02期

关键词：

allergy; asthma; birth cohorts; data accuracy; data harmonization; data pooling; data sharing; DATASHAPER APPROACH; CHILDHOOD ASTHMA; ATOPIC DISEASES; PROFILE; RHINITIS; ECZEMA; AGE; METAANALYSIS; ENVIRONMENT; POPULATION;

D O I：

10.1093/aje/kwy242

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.

引用

页码：408 / 417

页数：10

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