Design and discovery of protein dimerizers

被引：46
作者：
Clemons, PA
机构：
[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[2] Harvard Univ, Dept Chem & Biol Sci, Cambridge, MA 02138 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 01期
关键词：
D O I：
10.1016/S1367-5931(99)80020-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：112 / 115
页数：4
相关论文
共 27 条
[21]  
Seed B, 1994, Chem Biol, V1, P125, DOI 10.1016/1074-5521(94)90001-9
[22]   CONTROLLING SIGNAL-TRANSDUCTION WITH SYNTHETIC LIGANDS [J].
SPENCER, DM ;
WANDLESS, TJ ;
SCHREIBER, SL ;
CRABTREE, GR .
SCIENCE, 1993, 262 (5136) :1019-1024
[23]   High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications [J].
Stockwell, BR ;
Haggarty, SJ ;
Schreiber, SL .
CHEMISTRY & BIOLOGY, 1999, 6 (02) :71-83
[24]   Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays [J].
Tan, DS ;
Foley, MA ;
Shair, MD ;
Schreiber, SL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (33) :8565-8566
[25]   A small, nonpeptidyl mimic of granulocyte-colony-stimulating factor [J].
Tian, SS ;
Lamb, P ;
King, AG ;
Miller, SG ;
Kessler, L ;
Luengo, JI ;
Averill, L ;
Johnson, RK ;
Gleason, JG ;
Pelus, LM ;
Dillon, SB ;
Rosen, J .
SCIENCE, 1998, 281 (5374) :257-259
[26]   Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment [J].
Yang, JX ;
Symes, K ;
Mercola, M ;
Schreiber, SL .
CURRENT BIOLOGY, 1998, 8 (01) :11-18
[27]   A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells [J].
You, AJ ;
Jackman, RJ ;
Whitesides, GM ;
Schreiber, SL .
CHEMISTRY & BIOLOGY, 1997, 4 (12) :969-975
123