Design and discovery of protein dimerizers

被引：46
作者：
Clemons, PA
机构：
[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[2] Harvard Univ, Dept Chem & Biol Sci, Cambridge, MA 02138 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 01期
关键词：
D O I：
10.1016/S1367-5931(99)80020-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：112 / 115
页数：4
相关论文
共 27 条
[1]  
Abbas A.K., 1994, Cellular and molecular immunology
[2]  
Austin D J, 1994, Chem Biol, V1, P131, DOI 10.1016/1074-5521(94)90002-7
[3]   Higher order iminodiacetic acid libraries for probing protein-protein interactions [J].
Boger, DL ;
Goldberg, J ;
Jiang, WQ ;
Chai, WY ;
Ducray, P ;
Lee, JK ;
Ozer, RS ;
Andersson, CM .
BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (08) :1347-1378
[4]   Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale [J].
Borchardt, A ;
Liberles, SD ;
Biggar, SR ;
Crabtree, GR ;
Schreiber, SL .
CHEMISTRY & BIOLOGY, 1997, 4 (12) :961-968
[5]   A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX [J].
BROWN, EJ ;
ALBERS, MW ;
SHIN, TB ;
ICHIKAWA, K ;
KEITH, CT ;
LANE, WS ;
SCHREIBER, SL .
NATURE, 1994, 369 (6483) :756-758
[6]   Single-step synthesis of cell-permeable protein dimerizers that activate signal transduction and gene expression [J].
Diver, ST ;
Schreiber, SL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (22) :5106-5109
[7]   Targeting growth factor and cytokine receptors with recombinant peptide libraries [J].
Dower, WJ .
CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (03) :328-334
[8]   Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies [J].
Elliott, S ;
Lorenzini, T ;
Yanagihara, D ;
Chang, D ;
Elliott, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (40) :24691-24697
[9]  
FAN Z, 1994, J BIOL CHEM, V269, P27595
[10]   GENERAL-METHOD FOR RAPID SYNTHESIS OF MULTICOMPONENT PEPTIDE MIXTURES [J].
FURKA, A ;
SEBESTYEN, F ;
ASGEDOM, M ;
DIBO, G .
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1991, 37 (06) :487-493
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