Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat

被引：104

作者：

Shirwaikar, A ^{[1
]}

Khan, S

Malini, S

机构：

[1] Coll Pharmaceut Sci, Dept Pharmacognosy, Manipal, Karnataka, India

[2] Kasturba Med Coll & Hosp, Dept Pharmacol, Manipal, Karnataka, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 89卷 / 2-3期

关键词：

osteoporosis; Cissus quadrangularis; bone fragility; bone mineral density; biomechanical strength; tartrate resistant acid phosphatase (TRAP); alkaline phosphatase (ALP);

D O I：

10.1016/j.jep.2003.08.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750 mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifen (5.4 mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750 mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：245 / 250

页数：6