A re-evaluation of the risk of transfusion-transmitted HIV prevented by the exclusion of men who have sex with men from blood donation in England and Wales, 2005-2007

被引：20
作者：
Davison, K. L. [1 ,2 ]
Brant, L. J. [1 ,2 ]
Presanis, A. M. [3 ]
Soldan, K. [4 ]
机构：
[1] Immunisat Hepatitis & Blood Safety Dept, Hlth Protect Agcy, London NW9 5EQ, England
[2] NHS Blood & Transplant, London, England
[3] MRC Biostat Unit, London, England
[4] HIV & STI Dept, Hlth Protect Agcy, London, England
来源：
VOX SANGUINIS | 2011年 / 101卷 / 04期
基金：
英国医学研究理事会;
关键词：
blood donation; donor selection; HIV risk; men who have sex with men;
D O I：
10.1111/j.1423-0410.2011.01491.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and Objectives One component of the rationale for lifetime exclusion of men who have sex with men (MSM) from blood donation in the UK is the probable reduction in the risk of transfusion-transmitted HIV; this exclusion has recently been questioned. Materials and Methods Data about HIV in blood donors and MSM were analysed to estimate the risk of infectious donations entering the blood supply under different scenarios of donor selection criteria (and donor compliance) for MSM and a heterosexual group with increased risk of HIV. Results In 2005-2007, a change from lifetime exclusion of MSM to 5-year deferral or no deferral increased the point estimate of HIV risk by between 0.4 % and 7.4 % depending on compliance with the deferral (range 4 % to 15 %) and 26.5 % (range 180 % to 430 %) respectively. A change from a 12-month deferral of the high- risk heterosexual group to lifetime exclusion reduced the estimated risk by about 7.2 % (range 60 % to 90 %). Each point estimate was within the probable range of risk under the current criteria. Conclusion If prevalence is the only fbctor affected by a reduced deferral, then the increased risk of HIV is probably negligible. However, the impact of a change depends on compliance; if this stays the same or worsens, the risk is expected to increase because of more incident infections in MSM who donate blood. The risk of transfusion-transmitted HIV could probably he reduced further by improving compliance with any exclusion, particularly after recent risk behaviours.
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收藏
页码：291 / 302
页数：12
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