Food intake and serum persistent organic pollutants in the Greenlandic pregnant women: The ACCEPT sub-study

被引：56

作者：

Long, Manhai ^{[1
,2
]}

Knudsen, Ane-Kersti Skaarup ^{[1
,2
]}

Pedersen, Henning Sloth ^{[3
]}

Bonefeld-Jorgensen, Eva Cecilie ^{[1
,2
]}

机构：

[1] Aarhus Univ, Ctr Arctic Hlth, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, Unit Cellular & Mol Toxicol, Dept Publ Hlth, DK-8000 Aarhus C, Denmark

[3] Primary Hlth Care Ctr, Nuuk, Greenland

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2015年 / 529卷

关键词：

Contaminants; Pregnant; Diet; Lifestyle; Greenland; PLASMA FATTY-ACIDS; PERFLUORINATED COMPOUNDS; BIRTH-WEIGHT; PERFLUOROALKYL SUBSTANCES; ORGANOCHLORINE COMPOUNDS; EUROPEAN POPULATIONS; DIETARY-COMPOSITION; PROSPECTIVE COHORT; NORWEGIAN WOMEN; NORTHERN NORWAY;

D O I：

10.1016/j.scitotenv.2015.05.022

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The Greenlandic Inuit have high blood concentrations of environmental persistent organic pollutants (POPs). High POP concentrations have been associated with age, smoking and consumption of marine mammals. Studies have indicated that exposure to POPs during pregnancy may adversely affect fetal and child development. To assess geographical differences in diet, lifestyle and environmental contaminant exposure among pregnant women in Greenland, blood samples and questionnaire data were collected from 207 pregnant women in five Greenlandic regions (North, Disco Bay, West, South and East). Blood samples were analyzed for 11 organochlorine pesticides (OCPs), 14 polychlorinated biphenyls (PCBs), 5 polybrominated diphenyl ethers (PBDEs), 15 perfluoroalkylated substances (PFASs) and 63 metals. A trend of higher intake of marine mammals in the East and North regions was reflected by a higher n-3/n-6 fatty acid ratio. Participants in the East region tended also to have higher intake of terrestrial species. A significant higher seabird intake was seen for pregnant women in the West region. Significant regional differences were found for blood concentrations of PCBs, OCPs, PFASs and mercury, with higher levels in the North and East regions. PFASs were significantly associated with PCBs and OCPs inmost of the regions. In the North region, PFASs were associated with both selenium and mercury. No significant regional difference was observed for PBDEs. The regional differences of blood levels of POPs and mercury were related to differences in intake of the traditional food. Compared to earlier reports, decreased levels of legacy POPs, Hg and Pb and perfluorooctane sulfonate and perfluorooctanoic acid were observed, but the levels of PFAS congeners perfluorohexane sulfonate and perfluorononanoic acid were sustained. The detection of POPs and heavy metals in maternal blood indicates fetal exposure to these compounds possibly influencing fetal development. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：198 / 212

页数：15

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