Direct amidation of azoles with formamides via metal-free C-H activation in the presence of tert-butyl perbenzoate

被引：125
作者：
He, Tao [1 ]
Li, Hongji [1 ]
Li, Pinhua [1 ]
Wang, Lei [1 ,2 ]
机构：
[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China
[2] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 31期
基金：
美国国家科学基金会;
关键词：
CROSS-COUPLING REACTIONS; N-HETEROCYCLIC CARBENES; CATALYZED DIRECT ALKYNYLATION; ANTIFUNGAL AGENTS; DIRECT ALKYLATION; ROOM-TEMPERATURE; HIGHLY EFFICIENT; DIRECT AMINATION; CARBON-DIOXIDE; BOND FORMATION;
D O I：
10.1039/c1cc13086b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and simple method for the direct amidation of azoles with formamides has been developed. The reaction could occur smoothly in the presence of tert-butyl perbenzoate (TBPB) as an oxidant under metal-and base-free conditions. Direct dehydrogenative cross-coupling of formamides and azoles generated the corresponding products in good yields.
引用
收藏
页码：8946 / 8948
页数：3
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