Case of pure ovarian squamous cell carcinoma resistant to combination chemotherapy with paclitaxel and carboplatin but responsive to monotherapy with weekly irinotecan

被引：4

作者：

Nakamura, Yasuhiko ^{[1
]}

Kamei, Toshiaki ^{[2
]}

Shinagawa, Masahiro ^{[1
]}

Sakamoto, Yuka ^{[1
]}

Miwa, Ichiro ^{[1
]}

机构：

[1] Yamaguchi Grand Med Ctr, Dept Gynecol, Yamaguchi 7478511, Japan

[2] Yamaguchi Grand Med Ctr, Dept Pathol, Yamaguchi 7478511, Japan

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2015年 / 41卷 / 05期

关键词：

carboplatin; irinotecan; ovarian cancer; paclitaxel; squamous cell carcinoma; PHASE-II; CANCER; TRIAL;

D O I：

10.1111/jog.12631

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Primary ovarian squamous cell carcinoma is uncommon, and the optimal treatment strategy for this disease has not yet been established. A 71-year-old woman diagnosed with FIGO stage IIb pure ovarian squamous cell carcinoma underwent cytoreductive surgery followed by combination chemotherapy with paclitaxel and carboplatin. After the second treatment course, a recurrent mass grew rapidly, and serum tumor maker levels increased. Monotherapy with weekly irinotecan was then instituted. This second-line chemotherapy was remarkably effective, and the patient subsequently underwent complete interval debulking surgery with a pathological complete response after the third treatment course. Weekly irinotecan is an effective choice for primary ovarian squamous cell carcinoma resistant to combination chemotherapy with paclitaxel and carboplatin.

引用

页码：809 / 812

页数：4

共 11 条

[1] Phase II trial of irinotecan in patients with metastatic epithelial ovarian cancer or peritoneal cancer [J].

Bodurka, DC ;

Levenback, C ;

Wolf, JK ;

Gano, J ;

Wharton, JT ;

Kavanagh, JJ ;

Gershenson, DM .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (02) :291-297

[2] Evaluation of New Platinum-Based Treatment Regimens in Advanced-Stage Ovarian Cancer: A Phase III Trial of the Gynecologic Cancer InterGroup [J].

Bookman, Michael A. ;

Brady, Mark F. ;

McGuire, William P. ;

Harper, Peter G. ;

Alberts, David S. ;

Friedlander, Michael ;

Colombo, Nicoletta ;

Fowler, Jeffrey M. ;

Argenta, Peter A. ;

De Geest, Koen ;

Mutch, David G. ;

Burger, Robert A. ;

Swart, Ann Marie ;

Trimble, Edward L. ;

Accario-Winslow, Chrisann ;

Roth, Lawrence M. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (09) :1419-1425

[3] Remarkable response of primary squamous cell carcinoma of the ovary to paclitaxel and cisplatin [J].

Eltabbakh, GH ;

Hempling, RE ;

Recio, FO ;

O'Neill, CP .

OBSTETRICS AND GYNECOLOGY, 1998, 91 (05) :844-846

[4] Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: a phase 3, open-label, randomised controlled trial [J].

Katsumata, Noriyuki ;

Yasuda, Makoto ;

Takahashi, Fumiaki ;

Isonishi, Seiji ;

Jobo, Toshiko ;

Aoki, Doisuke ;

Tsuda, Hiroshi ;

Sugiyama, Toru ;

Kodama, Shoji ;

Kimura, Eizo ;

Ochiai, Kazunori ;

Noda, Kiichiro .

LANCET, 2009, 374 (9698) :1331-1338

[5] Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A clinicopathologic analysis [J].

Kikkawa, F ;

Ishikawa, H ;

Tamakoshi, K ;

Nawa, A ;

Suganuma, N ;

Tomoda, Y .

OBSTETRICS AND GYNECOLOGY, 1997, 89 (06) :1017-1022

[6] The safety and efficacy of the weekly dosing of irinotecan for platinum- and taxanes-resistant epithelial ovarian cancer [J].

Matsumoto, K ;

Katsumata, N ;

Yamanaka, Y ;

Yonemori, K ;

Kohno, T ;

Shimizu, C ;

Andoh, M ;

Fujiwara, Y .

GYNECOLOGIC ONCOLOGY, 2006, 100 (02) :412-416

[7] A case of rapidly growing ovarian squamous cell carcinoma successfully controlled by weekly paclitaxel-carboplatin administration [J].

Ohtani, K ;

Sakamoto, H ;

Masaoka, N ;

Shimada, K ;

Kanaeda, T ;

Kurihara, M ;

Nagai, N ;

Satoh, K .

GYNECOLOGIC ONCOLOGY, 2000, 79 (03) :515-518

[8] Primary squamous cell carcinoma of the ovary - Report of 37 cases [J].

Pins, MR ;

Young, RH ;

Daly, WJ ;

Scully, RE .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (07) :823-833

[9] A case of pure-type ovarian squamous cell carcinoma for which combination chemotherapy consisting of paclitaxel and carboplatin was not effective [J].

Todo, Y ;

Minobe, S ;

Sasaki, M ;

Yamamoto, R ;

Sakuragi, N .

GYNECOLOGIC ONCOLOGY, 2005, 97 (01) :223-227

[10] Phase II study of neoadjuvant chemotherapy with irinotecan hydrochloride and nedaplatin followed by radical hysterectomy for bulky stage Ib2 to IIb, cervical squamous cell carcinoma: Japanese Gynecologic Oncology Group study (JGOG 1065) [J].

Yamaguchi, Satoshi ;

Nishimura, Ryuichiro ;

Yaegashi, Nobuo ;

Kiguchi, Kazushige ;

Sugiyama, Toru ;

Kita, Tsunekazu ;

Kubushiro, Kaneyuki ;

Kokawa, Katsuji ;

Hiura, Masamichi ;

Mizutani, Katsumi ;

Yamamoto, Kaichiro ;

Takizawa, Ken .

ONCOLOGY REPORTS, 2012, 28 (02) :487-493

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