O2 and glutathione effects on water radiolysis: a simulation study

被引:15
|
作者
Colliaux, A. [1 ,2 ]
Gervais, B. [3 ]
Rodriguez-Lafrasse, C. [4 ]
Beuve, M. [1 ,2 ]
机构
[1] Univ Lyon 1, CNRS, UMR 5822, Inst Phys Nucl Lyon,IN2P3, F-69622 Lyon, France
[2] Univ Lyon 1, CNRS, UMR 5205, LIRIS, F-69622 Villeurbanne, France
[3] Ctr Res Ions Mat Photon, F-14070 Caen 05, France
[4] Univ Lyon 1, Fac Med Lyon Sud, Lab Radiobiol Cellulaire Mol, F-69921 Oullins, France
来源
COST CHEMISTRY CM0603-MELUSYN JOINT MEETING: DAMAGES INDUCED IN BIOMOLECULES BY LOW AND HIGH ENERGY RADIATIONS | 2011年 / 261卷
关键词
MONTE-CARLO-SIMULATION; LIQUID WATER; MULTIPLE IONIZATION; LIPID-PEROXIDATION; PROTON TRACKS; FAST-ELECTRON; ION THERAPY; K-VALUES; RADIATION; OXYGEN;
D O I
10.1088/1742-6596/261/1/012007
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
We present a MC simulation of water radiolysis when O-2 and glutathione are present in the solution. Our simulation is based on the continuum approximation proposed by Green and co-workers'. We investigate in particular the sensitivity of the yield of HO2 center dot+O-2(-center dot) to the concentration of O-2 and glutathione and to the LET of the ionising radiation. We demonstrate that the production of HO2 center dot/O-2(-center dot) is highly sensitive to these parameters and that the variation of their yield with the O-2 concentration shares remarkable similarities with the O-2 effect reported for biological cell damage efficiency
引用
收藏
页数:11
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