The role of annexin A1 in the modulation of the NLRP3 inflammasome

被引：35

作者：

Galvao, Izabela ^{[1
]}

de Carvalho, Renan V. H. ^{[2
]}

Vago, Juliana P. ^{[1
]}

Silva, Alexandre L. N. ^{[2
]}

Carvalho, Toniana G. ^{[3
]}

Antunes, Maisa M. ^{[1
]}

Ribeiro, Fabiola M. ^{[3
]}

Menezes, Gustavo B. ^{[1
]}

Zamboni, Dario S. ^{[2
]}

Sousa, Lirlandia P. ^{[4
]}

Teixeira, Mauro M. ^{[3
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Morfol, Belo Horizonte, MG, Brazil

[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biol Celular & Mol & Bioagentes Patogen, Sao Paulo, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Dept Anal Clin & Toxicol, Fac Farm, Belo Horizonte, MG, Brazil

来源：

IMMUNOLOGY | 2020年 / 160卷 / 01期

关键词：

annexin A1; IL-1; beta; inflammasome; NLRP3; NF-KAPPA-B; ANTIINFLAMMATORY DRUGS; RHEUMATOID-ARTHRITIS; PATTERN-RECOGNITION; CELL-DEATH; ACTIVATION; RESPONSES; INTERLEUKIN-1; STIMULATION; MACROPHAGES;

D O I：

10.1111/imm.13184

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Annexins are well-known Ca2+ phospholipid-binding proteins, which have a wide variety of cellular functions. The role of annexin A1 (AnxA1) in the innate immune system has focused mainly on the anti-inflammatory and proresolving properties through its binding to the formyl-peptide receptor 2 (FPR2)/ALX receptor. However, studies suggesting an intracellular role of AnxA1 are emerging. In this study, we aimed to understand the role of AnxA1 for interleukin (IL)-1 beta release in response to activators of the nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3) inflammasome. Using AnxA1 knockout mice, we observed that AnxA1 is required for IL-1 beta release in vivo and in vitro. These effects were due to reduction of transcriptional levels of IL-1 beta, NLRP3 and caspase-1, a step called NLRP3 priming. Moreover, we demonstrate that AnxA1 co-localize and directly bind to NLRP3, suggesting the role of AnxA1 in inflammasome activation is independent of its anti-inflammatory role via FPR2. Therefore, AnxA1 regulates NLRP3 inflammasome priming and activation in a FPR2-independent manner.

引用

页码：78 / 89

页数：12

共 61 条

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Zhao, Yin ;

Li, Xing ;

Gong, Jieling ;

Li, Lu ;

Chen, Liwen ;

Zheng, Lu ;

Chen, Zhiqi ;

Shi, Jing ;

Zhang, Hong .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (06) :1350-1358

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