Preparative chromatographic separation of neighboring lanthanides using amines as a pH adjusting additive for producing carrier-free 177Lu

被引：3

作者：

Kim, Aran ^{[1
]}

Choi, Kanghyuk ^{[1
]}

机构：

[1] Korea Atom Energy Res Inst, Radioisotope Res Div, 989-111 Daedeok Daero, Daejeon 34057, South Korea

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2022年 / 331卷 / 03期

关键词：

Cation-exchange chromatography; Lanthanide separation; Lutetium; Ytterbium; Amine; NO-CARRIER; ADDED LU-177; PART II; RADIOLANTHANIDES; YTTERBIUM; ELEMENTS; YB;

D O I：

10.1007/s10967-022-08216-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This study is a preliminary experiment to examine the effect of amines as additive in eluents for separating neighboring lanthanides (Lu and Yb) for efficiently producing carrier-free Lu-177. The separation method was based on cation-exchange chromatography and the pH-adjusted eluent with NH4OH or several amines. Among the amines, methylamine exhibited a longer retention time than NH4OH, and proved to be the most effective additive for separation resolution and purification. The optimized chromatographic parameters were able to effectively separate Lu from a large amount (100 mg) of Yb on a relatively short column (15 mm x 70 mm). [GRAPHICS] .

引用

页码：1451 / 1457

页数：7

共 25 条

[1] Rare earth elements: A review of applications, occurrence, exploration, analysis, recycling, and environmental impact [J].

Balaram, V. .

GEOSCIENCE FRONTIERS, 2019, 10 (04) :1285-1303

[2] SEPARATION OF CARRIER-FREE LU-177 FROM NEUTRON-IRRADIATED NATURAL YTTERBIUM TARGET [J].

BALASUBRAMANIAN, PS .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY-ARTICLES, 1994, 185 (02) :305-310

[3] Lutetium-177 Therapeutic Radiopharmaceuticals: Linking Chemistry, Radiochemistry, and Practical Applications [J].

Banerjee, Sharmila ;

Pillai, M. R. A. ;

Knapp, F. F. .

CHEMICAL REVIEWS, 2015, 115 (08) :2934-2974

[4] Chromatographic separation of thulium from erbium for neutron capture cross section measurements-Part II: Preparative scale separation [J].

Bene, Balazs J. ;

Taylor, Wayne A. ;

Birnbaum, Eva R. ;

Sudowe, Ralf .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2017, 311 (01) :155-163

[5] Separation of Yb as YbSO4 from the 176Yb target for production of 177Lu via the 176Yb(n, γ)177Yb→177Lu process [J].

Bilewicz, A. ;

Zuchowska, K. ;

Bartos, B. .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2009, 280 (01) :167-169

[6] Recycling of rare earths: a critical review [J].

Binnemans, Koen ;

Jones, Peter Tom ;

Blanpain, Bart ;

Van Gerven, Tom ;

Yang, Yongxiang ;

Walton, Allan ;

Buchert, Matthias .

JOURNAL OF CLEANER PRODUCTION, 2013, 51 :1-22

[7] An electro-amalgamation approach to isolate no-carrier-added 177Lu from neutron irradiated Yb for biomedical applications [J].

Chakravarty, Rubel ;

Das, Tapas ;

Dash, Ashutosh ;

Venkatesh, Meera .

NUCLEAR MEDICINE AND BIOLOGY, 2010, 37 (07) :811-820

[8] COMPLEXES OF THE LANTHANIDE ELEMENTS WITH ALPHA-HYDROXY CARBOXYLATE LIGANDS [J].

CHOPPIN, GR ;

CHOPOORIAN, JA .

JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1961, 22 (1-2) :97-113

[9] SEPARATION OF CARRIER-FREE HO-166 FROM NEUTRON-IRRADIATED DYSPROSIUM TARGETS [J].

DADACHOVA, E ;

MIRZADEH, S ;

LAMBRECHT, RM ;

HETHERINGTON, EL ;

KNAPP, FF .

ANALYTICAL CHEMISTRY, 1994, 66 (23) :4272-4277

[10] Production of 177Lu for Targeted Radionuclide Therapy: Available Options [J].

Dash A. ;

Pillai M.R.A. ;

Knapp F.F. ;

Jr. .

Nuclear Medicine and Molecular Imaging, 2015, 49 (2) :85-107

← 1 2 3 →