Hopeahainol A:: An acetylcholinesterase inhibitor from Hopea hainanensis

被引：148

作者：

Ge, Hui Ming ^{[1
]}

Zhu, Chun Hua ^{[1
]}

Shi, Da Hua ^{[1
]}

Zhang, Li Dong ^{[2
,3
]}

Xie, Dai Qian ^{[2
,3
]}

Yang, Jie ^{[1
]}

Ng, Seik Weng ^{[4
]}

Tan, Ren Xiang ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Key Lab Mesoscop Chem, Dept Chem, Nanjing 210093, Peoples R China

[3] Nanjing Univ, Key Lab Mesoscop Chem, Inst Theoret & Computat Chem, Nanjing 210093, Peoples R China

[4] Univ Malaya, Kuala Lumpur 50603, Malaysia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 01期

关键词：

hopeahainol; inhibitor; natural products; polyphenols; structure elucidation;

D O I：

10.1002/chem.200700960

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A phytochemical study of Hopea hainanensis has led to the isolation of three new polyphenols and one known compound. The most important of these compounds are hopeahainols A (2) and B (3), which contain an unprecedented carbon skeleton. The structures were elucidated by analysis of the spectroscopic data including single-crystal X-ray spectroscopy and computational methods. Hopeahainol A was an acetylcholinesterase inhibitor with an IC50 value of 4.33 mu m, which is comparable to that of huperzine A, a presently prescribed drug for the treatment of Alzheimer, while other similar structures were inactive. This observation was complemented by a 3D interaction model of the inhibitor with active sites.

引用

页码：376 / 381

页数：6

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