The Role of the Immune System in the Development of Endometriosis

被引：90

作者：

Abramiuk, Monika ^{[1
]}

Grywalska, Ewelina ^{[2
]}

Malkowska, Paulina ^{[3
,4
]}

Sierawska, Olga ^{[3
,4
]}

Hrynkiewicz, Rafal ^{[3
]}

Niedzwiedzka-Rystwej, Paulina ^{[3
]}

机构：

[1] Med Univ Lublin, Dept Gynecol Oncol & Gynecol, PL-20081 Lublin, Poland

[2] Med Univ Lublin, Dept Expt Immunol, PL-20093 Lublin, Poland

[3] Univ Szczecin, Inst Biol, PL-71412 Szczecin, Poland

[4] Univ Szczecin, Doctoral Sch, PL-71412 Szczecin, Poland

来源：

CELLS | 2022年 / 11卷 / 13期

关键词：

endometriosis; immune system; cytokine; defensins; NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B; PERITONEAL-FLUID MACROPHAGES; ENDOTHELIAL GROWTH-FACTOR; KILLER-CELL ACTIVITY; REGULATORY T-CELLS; STROMAL CELLS; PROGRAMMED DEATH-1; INTERFERON-GAMMA; ENHANCED EXPRESSION;

D O I：

10.3390/cells11132028

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endometriosis is a chronic disease that affects about 10% of women of reproductive age. It can contribute to pelvic pain, infertility or other conditions such as asthma, cardiovascular disease, breast or ovarian cancer. Research has shown that one of the conditions for the development of endometrial lesions is the dysfunction of the immune system. It appears that immune cells, such as neutrophils, macrophages, NK cells and dendritic cells, may play a specific role in the angiogenesis, growth and invasion of endometriosis cells. Immune cells secrete cytokines and defensins that also affect the endometriosis environment. This review discusses the various components of the immune system that are involved in the formation of endometrial lesions in women.

引用

页数：23

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