Role of miR-155 in immune regulation and its relevance in oral lichen planus

被引：25

作者：

Tao, Yan ^{[1
]}

Ai, Ruixue ^{[1
]}

Hao, Yilong ^{[1
]}

Jiang, Lu ^{[1
]}

Dan, Hongxia ^{[1
]}

Ji, Ning ^{[1
]}

Zeng, Xin ^{[1
]}

Zhou, Yu ^{[1
]}

Chen, Qianming ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis,Dept Oral Med, 14 Sect 3 Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2019年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

oral lichen planus; microRNA-155; immune system; potential pathways; targets; NF-KAPPA-B; CD8(+) T-CELLS; DENDRITIC CELLS; CLINICAL-FEATURES; MICRORNA-155; ACTIVATION; EXPRESSION; INFLAMMATION; PATHOGENESIS; SUPPRESSOR;

D O I：

10.3892/etm.2018.7019

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Oral lichen planus (OLP) is a chronic mucosal inflammatory disease. The World Health Organization has described it as a potentially malignant condition. The pathogenesis of OLP remains to be fully elucidated, but extensive evidence suggests that immunologic and inflammatory factors have important roles. MicroRNAs (miRs), which are small non-coding RNAs, have been reported to be involved in OLP. In particular, miR-155 is significantly upregulated in patients with OLP. miR-155 has numerous functions and is closely linked to inflammation and immune system regulation. However, in-depth studies of the mechanisms via which miR-155 is involved in OLP are currently insufficient. Considering the close association between miR-155 and immune regulation as well as the importance of immune factors in OLP, the role of miR-155 in the immune system was herein summarized with a focus on OLP. The present review provides a basis for further study of the molecular mechanisms underlying the development and progression of OLP.

引用

页码：575 / 586

页数：12

共 104 条

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