Synthesis and biological evaluation of a heparin-like hexasaccharide with the structural motifs for binding to FGF and FGFR

被引：45
作者：
de Paz, JL
Martin-Lomas, M
机构：
[1] CSIC, Grp Carbohidratos, Inst Invest Quim, Seville 41092, Spain
[2] Cty Amer Vespucio, Seville 41092, Spain
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 09期
关键词：
growth factor activation; heparin; synthesis design; oligosaccharides; carbohydrates;
D O I：
10.1002/ejoc.200400799
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A heparin-like hexasaccharide structure (2) containing the two trisaccharide sequences that interact with acidic fibroblast growth factor (FGF-1) and with its receptor (FGFR) has been designed on the basis of crystallographic data. This hexasaccharide has been effectively synthesized by a completely stereoselective modular approach and biologically evaluated by determination of its capacity to stimulate FGF-1-induced mitogenic activity. It was found that this molecule did not show an appreciable FGF-1 activating effect. (c) Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1849 / 1858
页数：10
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