Unmet needs in Parkinson's disease: New horizons in a changing landscape

被引：16
作者：
Chaudhuri, K. Ray [1 ,2 ]
Bhidayasiri, Roongroj [3 ,4 ,5 ]
van Laar, Teus [6 ]
机构：
[1] Kings Coll London, Maurice Wohl Clin Neurosci Inst, London, England
[2] Kings Coll Hosp London, Natl Parkinson Fdn Ctr Excellence, London, England
[3] Chulalongkorn Univ, Fac Med, Dept Med, Chulalongkorn Ctr Excellence Parkinsons Dis & Rel, Bangkok, Thailand
[4] King Chulalongkorn Mem Hosp, Bangkok, Thailand
[5] Juntendo Univ, Dept Rehabil Med, Tokyo, Japan
[6] Univ Groningen, Dept Neurol, Groningen, Netherlands
来源：
PARKINSONISM & RELATED DISORDERS | 2016年 / 33卷
关键词：
Parkinson's disease; Unmet needs; Pathogenesis; Non-motor symptoms; Service provision;
D O I：
10.1016/j.parkreldis.2016.11.018
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The success of levodopa and other classes of drugs have meant that most people with Parkinson's disease enjoy a good quality of life for many years. However, despite the availability of several drugs and formulations that can be used as monotherapy and in combination, there are a number of disease features that the current therapies are unable to address. The disease continues to progress despite treatment, patients suffer from a myriad of motor and non-motor symptoms, and a neuroprotective therapy is urgently required. To move forward with medical and surgical management, it is important to consider new insights that recent research offers and in this review we examine how a better understanding of the disease pathology and progression might improve and enrich our daily clinical practice. It is also timely to consider the service provision changes that will increasingly be needed to effectively manage the needs of the aging population. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：S2 / S8
页数：7
相关论文
共 99 条
[1]  
All Party Parliamentary Group for Parkinson's Disease, 2009, PLEAS MIND GAP PARK
[2]  
[Anonymous], 2011, EUROPEAN PARKINSONS
[3]   Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease [J].
Appleman, Erica R. ;
Stavitsky, Karina ;
Cronin-Golomb, Alice .
PARKINSONS DISEASE, 2011, 2011
[4]   Endpoints and Analyses to Discern Disease-Modifying Drug Effects in Early Parkinson's Disease [J].
Bhattaram, Venkatesh Atul ;
Siddiqui, Ohidul ;
Kapcala, Leonard P. ;
Gobburu, Jogarao V. S. .
AAPS JOURNAL, 2009, 11 (03) :456-464
[5]   Effective Delivery of Apomorphine in the Management of Parkinson Disease: Practical Considerations for Clinicians and Parkinson Nurses [J].
Bhidayasiri, Roongroj ;
Chaudhuri, K. Ray ;
LeWitt, Peter ;
Martin, Anne ;
Boonpang, Kamolwan ;
van Laar, Teus .
CLINICAL NEUROPHARMACOLOGY, 2015, 38 (03) :89-103
[6]   Nocturnal journey of body and mind in Parkinson's disease: the manifestations, risk factors and their relationship to daytime symptoms. Evidence from the NIGHT-PD study [J].
Bhidayasiri, Roongroj ;
Mekawichai, Pawut ;
Jitkritsadakul, Onanong ;
Panyakaew, Pattamon ;
Kaewwilai, Lalita ;
Boonrod, Nonglak ;
Petchrutchatachart, Sitthi ;
Jagota, Priya ;
Boonpeng, Kamolwan ;
Singmaneesakulchai, Surat ;
Setthawatcharawanich, Suwanna .
JOURNAL OF NEURAL TRANSMISSION, 2014, 121 :S59-S68
[7]  
Blindauer K, 2006, ARCH NEUROL-CHICAGO, V63, P210
[8]   Staging of brain pathology related to sporadic Parkinson's disease [J].
Braak, H ;
Del Tredici, K ;
Rüb, U ;
de Vos, RAI ;
Steur, ENHJ ;
Braak, E .
NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211
[9]   Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies [J].
Burn, DJ ;
Rowan, EN ;
Allan, LM ;
Molloy, S ;
T O'Brien, J ;
McKeith, IG .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2006, 77 (05) :585-589
[10]   Impact of the motor complications of Parkinson's disease on the quality of life [J].
Chapuis, S ;
Ouchchane, L ;
Metz, O ;
Gerbaud, L ;
Durif, F .
MOVEMENT DISORDERS, 2005, 20 (02) :224-230
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