Variation in global DNA hydroxymethylation with age associated with schizophrenia

被引：18

作者：

Jiang, Tingyun ^{[1
,2
]}

Zong, Lu ^{[3
,4
]}

Zhou, Lin ^{[5
]}

Hou, Yu ^{[3
,4
]}

Zhang, Lulu ^{[6
]}

Zheng, Xianzhen ^{[7
,8
]}

Han, Hongying ^{[9
]}

Li, Shufen ^{[3
,4
]}

Zhang, Wenwei ^{[2
]}

Zhang, Jian ^{[3
,4
]}

Deng, Cong ^{[10
]}

Jia, Yanbin ^{[1
]}

Zhao, Cunyou ^{[3
,4
]}

机构：

[1] Jinan Univ, Affiliated Hosp 1, Dept Psychiat, Guangzhou, Guangdong, Peoples R China

[2] Third Peoples Hosp Zhongshan, Zhongshan, Guangdong, Peoples R China

[3] Southern Med Univ, Sch Basic Med Sci, Dept Med Genet, Guangzhou 510515, Guangdong, Peoples R China

[4] Guangdong Technol & Engn Res Ctr Mol Diagnost Hum, Guangzhou, Guangdong, Peoples R China

[5] Family Planning Inst Hunan Prov, Key Lab Genet & Birth Hlth Hunan Prov, Changsha, Hunan, Peoples R China

[6] Guangzhou First Peoples Hosp, Dept Psychiat, Guangzhou, Guangdong, Peoples R China

[7] Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China

[8] Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China

[9] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Psychiat, Guangzhou, Guangdong, Peoples R China

[10] Guangzhou Med Univ, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China

来源：

PSYCHIATRY RESEARCH | 2017年 / 257卷

基金：

中国国家自然科学基金;

关键词：

5hmC; 5mC; DNA modifications; LEUKOCYTE DNA; METHYLATION; 5-HYDROXYMETHYLCYTOSINE; DEMETHYLATION; DISORDERS; GENES; BLOOD;

D O I：

10.1016/j.psychres.2017.08.022

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

To improve understanding of DNA hydroxymethylation (5hmC) and methylation (5mC) in the development of schizophrenia, this study examined global 5hmC and 5mC levels in peripheral blood DNA of 264 patients with schizophrenia and 221 controls and observed increased 5mC levels in the patients and increased 5hmC levels in male patients but decreased levels in female patients as compared with the controls. The 5mC level displayed a gender-dependent positive correlation with age and the 5hmC level displayed a correlation with age positively in controls but negatively in patients, and their role in the pathogenesis of schizophrenia remains to be elucidated.

引用

页码：497 / 500

页数：4

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