Effects of Jen-San-Yaung-Jung-Tang on scopolamine-induced amnesia in rats

被引：2
作者：
Lu, MC [1 ]
机构：
[1] China Med Coll, Grad Inst Tradit Chinese Med, Taichung, Taiwan
来源：
AMERICAN JOURNAL OF CHINESE MEDICINE | 1998年 / 26卷 / 02期
关键词：
D O I：
10.1142/S0192415X98000166
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The effect of Jen-San-Yaung-Jung-Tang (YJT) on scopolamine (SCOP)-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that YJT (0.5 and 1.0 g/kg) significantly improved SCOP-induced amnesia and did not change the horizontal activity and pain threshold. YJT at 0.5 and 1.0 g/kg also did not change SCOP-treated horizontal activity and pain threshold. Furthermore, the antiamnesic effect of YJT at 1.0 g/kg on the SCOP-induced amnesia was augmented by physostigmine, but was not altered by neostigmine or scopolamine N-methylbromide. These results suggest that the antiamnesic effect of YJT could only be related to the memory-related process, and to an increase in central cholinergic neuronal activity.
引用
收藏
页码：117 / 126
页数：10
相关论文
共 21 条
[1]   THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].
BARTUS, RT ;
DEAN, RL ;
BEER, B ;
LIPPA, AS .
SCIENCE, 1982, 217 (4558) :408-417
[2]   PATTERNS OF MEMORY FAILURE AFTER SCOPOLAMINE TREATMENT - IMPLICATIONS FOR CHOLINERGIC HYPOTHESES OF DEMENTIA [J].
BEATTY, WW ;
BUTTERS, N ;
JANOWSKY, DS .
BEHAVIORAL AND NEURAL BIOLOGY, 1986, 45 (02) :196-211
[3]  
CHEN CJS, 1993, PHARM APPL NOVEL CHI, P297
[4]   A COMPARISON OF THE EFFECTS OF SCOPOLAMINE AND DIAZEPAM ON ACQUISITION AND RETENTION OF INHIBITORY AVOIDANCE IN MICE [J].
DECKER, MW ;
TRAN, T ;
MCGAUGH, JL .
PSYCHOPHARMACOLOGY, 1990, 100 (04) :515-521
[5]   HUMAN MEMORY AND CHOLINERGIC SYSTEM - RELATIONSHIP TO AGING [J].
DRACHMAN, DA ;
LEAVITT, J .
ARCHIVES OF NEUROLOGY, 1974, 30 (02) :113-121
[6]   AN EVALUATION OF THE MECHANISM OF SCOPOLAMINE-INDUCED IMPAIRMENT IN 2 PASSIVE-AVOIDANCE PROTOCOLS [J].
ELROD, K ;
BUCCAFUSCO, JJ .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 29 (01) :15-21
[7]   SCOPOLAMINE EFFECTS ON MEMORY RETENTION IN MICE - A MODEL OF DEMENTIA [J].
FLOOD, JF ;
CHERKIN, A .
BEHAVIORAL AND NEURAL BIOLOGY, 1986, 45 (02) :169-184
[8]  
HUANG TK, 1996, CHINESE PRESCRIPTION, P35
[9]  
MOHS RC, 1985, AM J PSYCHIAT, V142, P28
[10]   DO PIRACETAM-LIKE COMPOUNDS ACT CENTRALLY VIA PERIPHERAL MECHANISMS [J].
MONDADORI, C ;
PETSCHKE, F .
BRAIN RESEARCH, 1987, 435 (1-2) :310-314
123