Vitamin E metabolism

被引：40

作者：

Wu, J. H. ^{[1
]}

Croft, K. D. ^{[1
]}

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, GPO Perth, WA 6847, Australia

来源：

MOLECULAR ASPECTS OF MEDICINE | 2007年 / 28卷 / 5-6期

基金：

英国医学研究理事会;

关键词：

metabolism; tocopheryl quinone; carboxyethyl-hydroxychromans; Simon metabolites; cytochrome p450; 5-nitro-gamma-CEHC; CHROMATOGRAPHY-MASS-SPECTROMETRY; INCREASE ALPHA-TOCOPHEROL; GAMMA-TOCOPHEROL; OXIDATIVE STRESS; DRUG-METABOLISM; CYCLOSPORINE-A; HEPG2; CELLS; IN-VIVO; ANTIOXIDANT; SUPPLEMENTATION;

D O I：

10.1016/j.mam.2006.12.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this paper is to provide an overview of vitamin E metabolism. The topics covered include: major classes of vitamin E metabolites; their production pathways and route of excretion; possible biological activities of vitamin E metabolites; and use of vitamin E metabolites as markers of oxidant generation. Recent investigations into vitamin E metabolism have also highlighted important new areas of research, such as the potential for high dose vitamin E supplementation to interfere with drug metabolism, as well as alternative methods to alter vitamin E bioavailability in vivo. These issues will also be discussed in the review. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：437 / 452

页数：16

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