miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis

被引：190

作者：

Kole, Adam J. ^{[1
,2
]}

Swahari, Vijay ^{[2
]}

Hammond, Scott M. ^{[1
]}

Deshmukh, Mohanish ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Ctr Neurosci, Chapel Hill, NC 27599 USA

来源：

GENES & DEVELOPMENT | 2011年 / 25卷 / 02期

关键词：

apoptosis; neurons; miRNAs; BH3-only; miR-29; Bcl-2; family; TROPHIC FACTOR DEPENDENCE; BCL-2; FAMILY-MEMBER; CELL-DEATH; EXPRESSION; PROTEINS; SURVIVAL; PATHWAY; BAX; MICRORNAS; RNAS;

D O I：

10.1101/gad.1975411

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The execution of apoptosis is critical for proper development of the nervous system. However, it is equally important that neurons strictly inhibit apoptosis after development to ensure their survival throughout the lifetime of the organism. Here we show that a micro-RNA, miR-29b, is markedly induced with neuronal maturation and functions as a novel inhibitor of neuronal apoptosis. The prosurvival function of miR-29b is mediated by targeting genes in the proapoptotic BH3-only family. Our results identify a unique strategy evolved by maturing neurons that uses a single microRNA to inhibit the multiple, redundant BH3-only proteins that are key initiators of apoptosis.

引用

页码：125 / 130

页数：6

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