Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus

被引：62

作者：

Francavilla, Ruggiero ^{[1
,2
]}

Villette, Vincent ^{[1
,2
]}

Luo, Xiao ^{[1
,2
]}

Chamberland, Simon ^{[2
]}

Munoz-Pino, Einer ^{[1
,2
]}

Camire, Olivier ^{[1
,2
]}

Wagner, Kristina ^{[3
]}

Kis, Viktor ^{[3
]}

Somogyi, Peter ^{[3
]}

Topolnik, Lisa ^{[1
,2
]}

机构：

[1] Univ Laval, CHU Quebec, Res Ctr, Neurosci Axis, Quebec City, PQ G1V 4G2, Canada

[2] Univ Laval, Dept Biochem Microbiol & Bioinformat, Quebec City, PQ G1V 0A6, Canada

[3] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

英国惠康基金; 加拿大健康研究院; 英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

VASOACTIVE INTESTINAL POLYPEPTIDE; PRIMARY SOMATOSENSORY CORTEX; IMMUNOREACTIVE INTERNEURONS; EXPRESSING CHOLECYSTOKININ; THETA-ON; CELLS; FREQUENCY; CIRCUIT; PARVALBUMIN; PROJECTIONS;

D O I：

10.1038/s41467-018-07162-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

GABAergic interneurons in the hippocampus provide for local and long-distance coordination of neurons in functionally connected areas. Vasoactive intestinal peptide-expressing (VIP+) interneurons occupy a distinct niche in circuitry as many of them specialize in innervating GABAergic cells, thus providing network disinhibition. In the CA1 hippocampus, VIP+ interneuron-selective cells target local interneurons. Here, we discover a type of VIP+ neuron whose axon innervates CA1 and also projects to the subiculum (VIP-LRPs). VIP-LRPs show specific molecular properties and target interneurons within the CA1 area but both interneurons and pyramidal cells within subiculum. They are interconnected through gap junctions but demonstrate sparse spike coupling in vitro. In awake mice, VIP-LRPs decrease their activity during theta-run epochs and are more active during quiet wakefulness but not coupled to sharp-wave ripples. Together, the data provide evidence for VIP interneuron molecular diversity and functional specialization in controlling cell ensembles along the hippocampo-subicular axis.

引用

页数：17

共 70 条

[1] Correlated morphological and neurochemical features identify different subsets of vasoactive intestinal polypeptide-immunoreactive interneurons in rat hippocampus [J].