Hot embossing of plastic microfluidic devices using poly(dimethylsiloxane) molds

被引:83
作者
Goral, Vasiliy N. [1 ]
Hsieh, Yi-Cheng
Petzold, Odessa N. [1 ]
Faris, Ronald A. [1 ]
Yuen, Po Ki [1 ]
机构
[1] Corning Inc, Sci & Technol, Corning, NY 14831 USA
关键词
D O I
10.1088/0960-1317/21/1/017002
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
We present a poly(dimethylsiloxane) (PDMS)-based hot embossing process for low-cost rapid prototyping of plastic microfluidic devices. Unlike the conventional hot embossing process, the process presented here uses a 2 mm thick PDMS mold, two 3/4 '' wide binder clips, two standard 1 mm thick 1 '' x 3 '' microscope glass slides and a standard laboratory oven. Micro-scale features were successfully replicated in 1.5 mm thick polystyrene slides from various PDMS molds. Also, the PDMS molds can be reused for many replications without any damage.
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页数:8
相关论文
共 17 条
[1]   Plastic advances microfluidic devices. [J].
Boone, T ;
Fan, ZH ;
Hooper, H ;
Ricco, A ;
Tan, HD ;
Williams, S .
ANALYTICAL CHEMISTRY, 2002, 74 (03) :78A-86A
[2]  
Carvalho B. L., 2003, P 7 INT C MIN CHEM B, P959
[3]   Aligned carbon nanotubes for nanoelectronics [J].
Choi, WB ;
Bae, E ;
Kang, D ;
Chae, S ;
Cheong, BH ;
Ko, JH ;
Lee, EM ;
Park, W .
NANOTECHNOLOGY, 2004, 15 (10) :S512-S516
[4]   Rapid prototyping of microfluidic systems in poly(dimethylsiloxane) [J].
Duffy, DC ;
McDonald, JC ;
Schueller, OJA ;
Whitesides, GM .
ANALYTICAL CHEMISTRY, 1998, 70 (23) :4974-4984
[5]   Rapid replication of master structures by double casting with PDMS [J].
Gitlin, Leonid ;
Schulze, Philipp ;
Belder, Detlev .
LAB ON A CHIP, 2009, 9 (20) :3000-3002
[6]  
Hardt DE, 2004, PROCESS CONTROL MICR
[7]  
Laermer F., 1996, United States Patent, Patent No. [5,501,893, 5501893, US005501893A, 005501893]
[8]   Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices [J].
Lee, JN ;
Park, C ;
Whitesides, GM .
ANALYTICAL CHEMISTRY, 2003, 75 (23) :6544-6554
[9]  
Maurya Devendra K., 2007, Biotechnology Journal, V2, P1381, DOI 10.1002/biot.200700107
[10]   Polymer embossing tools for rapid prototyping of plastic microfluidic devices [J].
Narasimhan, J ;
Papautsky, I .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2004, 14 (01) :96-103