C57BL/6 mice infected with Neospora caninum during administration of progesterone show bias toward type 2 immune response

被引:6
|
作者
Kano, Rika
Kudo, Akimasa
Kamiya, Hikaru
Kobayashi, Yoshiyasu
Maeda, Ryuichiro
Omata, Yoshitaka [1 ]
机构
[1] Obihiro Univ Agr & Vet Med, Sch Vet Med, Dept Vet Basic Sci, Obihiro, Hokkaido 0808555, Japan
[2] Hokkaido Univ, Grad Sch Vet Med, Dept Dis Control, Infect Dis Lab,Kita Ku, Sapporo, Hokkaido 0600818, Japan
[3] Obihiro Univ Agr & Vet Med, Sch Vet Med, Dept Vet Pathobiol Sci, Obihiro, Hokkaido, Japan
来源
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2007年 / 69卷 / 10期
关键词
immune responses; Neospora caninum; progesterone;
D O I
10.1292/jvms.69.1095
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
To clarify the role of progesterone in the development of immune responses during pregnancy against Neospora caninum infection, C57BL/6 mice were given a progesterone pellet, and measured on Interferon-gamma and interleukin-4 production following the infection. IFN-gamma production in the prescribed group was significantly lower than that in the intact group on day 40 post administration. IL-4 producing cell population in the prescribed group was larger than that in the intact group. These results suggest that progesterone may alter the balance of cytokine production, and that the bias toward type 2 immune response may remain for a certain period after the infection.
引用
收藏
页码:1095 / 1097
页数:3
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