Uterine tumors resembling ovarian sex cord-stromal tumors: synchronous uterine tumors resembling ovarian sex cord-stromal tumors and ovarian sex cord tumor

被引:20
作者
Abdullazade, Samir
Kosemehmetoglu, Kemal
Adanir, Ilknur [2 ]
Kutluay, Lale [3 ]
Usubutun, Alp [1 ]
机构
[1] Hacettepe Univ, Fac Med, Dept Pathol, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Dept Obstet & Gynecol, TR-06100 Ankara, Turkey
[3] Genel Pathol Ctr, TR-06440 Ankara, Turkey
关键词
Uterus; UTROSCT; Granulosa cell tumor; Immunohistochemistry; CONSERVATIVE-MANAGEMENT; NEOPLASMS; DIFFERENTIATION; INHIBIN; MARKER;
D O I
10.1016/j.anndiagpath.2010.07.001
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Uterine tumors resembling ovarian sex cord-stromal tumors (UTROSCTs) are very rare. In this article, we present 3 cases that manifest classical histomorphological features alongside diverse immunohistochemical findings. As a distinctive finding, one of the patients had UTROSCT in the uterus and an ovarian sex cord tumor, called granulosa cell tumor, in the left ovary, simultaneously. Problems in diagnosing such pathologic condition generally arise because of the variable histologic picture of UTROSCT and may cause problems for general and other nongynecologic surgical pathologists. Immunohistochemically, these tumors express different markers that indicate their polyphenotypic origins. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:432 / 437
页数:6
相关论文
共 27 条
[11]   Uterine tumour resembling ovarian sex cord tumour is an immunohistochemically polyphenotypic neoplasm which exhibits coexpression of epithelial, myoid and sex cord markers [J].
Hurrell, D. P. ;
McCluggage, W. G. .
JOURNAL OF CLINICAL PATHOLOGY, 2007, 60 (10) :1148-1154
[12]   Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation [J].
Irving, JA ;
Carinelli, S ;
Prat, J .
MODERN PATHOLOGY, 2006, 19 (01) :17-24
[13]   Uterine tumor resembling ovarian sex-cord tumor:: Report of a case mimicking cervical adenocarcinoma [J].
Kabbani, W ;
Deavers, MT ;
Malpica, A ;
Burke, TW ;
Liu, JS ;
Ordoñez, NG ;
Jhingran, A ;
Silva, EG .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2003, 22 (03) :297-302
[14]   Uterine tumors resembling ovarian sex-cord tumors have an immunophenotype consistent with true sex-cord differentiation [J].
Krishnamurthy, S ;
Jungbluth, AA ;
Busam, KJ ;
Rosai, J .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1998, 22 (09) :1078-1082
[15]  
LANGLEY F A, 1953, Acta Obstet Gynecol Scand, V32, P143
[16]   CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors [J].
McCluggage, W. Glenn ;
McKenna, Michael ;
McBride, Hilary A. .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2007, 26 (03) :322-327
[17]  
MOREHEAD RP, 1945, AM J PATHOL, V21, P53
[18]  
Motiwala Nisrin, 2006, Arch Pathol Lab Med, V130, pe74
[19]   Calretinin, a more sensitive but less specific marker than α-inhibin for ovarian sex cord-stromal neoplasms -: An immunohistochemical study of 215 cases [J].
Movahedi-Lankarani, S ;
Kurman, RJ .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (11) :1477-1483
[20]   An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus - A study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies [J].
Oliva, E ;
Young, RH ;
Amin, MB ;
Clement, PB .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (04) :403-412