Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome

被引:51
作者
Fortuna, A. M. [1 ,2 ,3 ]
Miralda, R. [1 ,2 ,3 ]
Calaf, N. [2 ,3 ]
Gonzalez, M. [2 ,3 ]
Casan, P. [2 ,3 ]
Mayos, M. [1 ,2 ,3 ]
机构
[1] Hosp Santa Creu & Sant Pau, Sleep Lab, Dept Resp Med, Barcelona 08025, Spain
[2] Hosp Santa Creu & Sant Pau, Dept Resp Med, Pulm Funct Lab, Barcelona 08025, Spain
[3] Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
关键词
Obstructive sleep apnea; Exhaled nitric oxide; Alveolar nitric oxide; Oxidative stress; OXIDATIVE STRESS; DAYTIME SLEEPINESS; PRESSURE; INFLAMMATION; NO;
D O I
10.1016/j.rmed.2010.12.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Study objectives: The process of intermittent hypoxia-reoxygenation produces airway inflammation and endothelial dysfunction that favors the development of cardiovascular disorders in obstructive sleep apnea syndrome (OSAS). Nitric oxide (NO) is an important mediator in airway inflammation and the regulation of endothelium-dependent vasodilation. Design: This study compared airway NO (FENO) and alveolar NO (CA(NO)) measurements in exhaled breath in 30 OSAS patients to those of 30 healthy (non-OSAS) individuals and determined the relationship between NO levels and OSAS severity. Additionally, NO measurements were analyzed after 3 months of CPAP treatment. Measurements and results: The mean (+/- SD) FEN level in the OSAS group (27.2 +/- 18 ppb) was higher than in the healthy non-OSAS group (p = 0.006). The mean CAN level was 1.65 +/- 0.90 ppb, lower than in the non-OSAS group (p = 0.001). A significant correlation was found between FENO and CA(NO) levels and the apnea hypopnea index (AHI) in the OSAS group (r = 0.8, p < 0.05; r = -0.9, p = 0.01, respectively). FENO levels decreased and CA(NO) levels increased significantly after CPAP treatment. Conclusions: Severe OSAS patients have higher FENO and lower CA(NO) levels and these are restored to normal after CPAP treatment, reflecting the correction of local upper airway inflammation and endothelial dysfunction present in OSAS patients. Exhaled breath techniques can be useful to identify airway inflammation and endothelial dysfunction in severe OSAS patients. (c) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:630 / 636
页数:7
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